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6-[(1E,3E)-1,3-Dimethyl-4-(4-nitrophenyl)-1,3-butadienyl]-4-methoxy-3-methyl-2H-pyran-2-one, also known as Luteoreticulin, is a rare nitrophenyl pyranone closely related to aureothin, neoaureothin, and its unusual photoisomers SNF4435C and SNF4435D. It is a potent antitumor agent with pronounced immunosuppressive activity and has been shown to reverse multi-drug resistance.

22388-89-2

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22388-89-2 Usage

Uses

Used in Pharmaceutical Industry:
6-[(1E,3E)-1,3-Dimethyl-4-(4-nitrophenyl)-1,3-butadienyl]-4-methoxy-3-methyl-2H-pyran-2-one is used as an antitumor agent for its potent antitumor properties and pronounced immunosuppressive activity. It is particularly effective in reversing multi-drug resistance, making it a promising candidate for the development of novel cancer therapies.
Used in Immunosuppressive Applications:
6-[(1E,3E)-1,3-Dimethyl-4-(4-nitrophenyl)-1,3-butadienyl]-4-methoxy-3-methyl-2H-pyran-2-one is used as an immunosuppressive agent due to its pronounced immunosuppressive activity. This makes it a potential candidate for the treatment of autoimmune diseases and transplantation medicine, where immunosuppression is required to prevent organ rejection.
The lack of availability of 6-[(1E,3E)-1,3-Dimethyl-4-(4-nitrophenyl)-1,3-butadienyl]-4-methoxy-3-methyl-2H-pyran-2-one has hitherto restricted a more intensive investigation of this interesting metabolite. However, its unique properties and potential applications make it a promising candidate for further research and development in the pharmaceutical and medical fields.

Check Digit Verification of cas no

The CAS Registry Mumber 22388-89-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,3,8 and 8 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 22388-89:
(7*2)+(6*2)+(5*3)+(4*8)+(3*8)+(2*8)+(1*9)=122
122 % 10 = 2
So 22388-89-2 is a valid CAS Registry Number.

22388-89-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(4-methoxy-2-methyl-2H-pyran-2-on-6-yl)-2,4-dimethyl-1-(4-nitrophenyl)-1,3-butadiene

1.2 Other means of identification

Product number -
Other names LUTEORETICULIN (GRISEULIN)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:22388-89-2 SDS

22388-89-2Downstream Products

22388-89-2Relevant academic research and scientific papers

Convergent syntheses of luteoreticulin and didemethylluteoreticulin

Lyga

, p. 515 - 518 (1995)

Convergent syntheses of luteoreticulin (1a) and didemethylluteoreticulin (1c) are described which are ammenable to structural variation in both the pyran and phenyl rings.

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