223907-76-4Relevant academic research and scientific papers
Functionalised bicyclic alcohols by enantioselective α-deprotonation-rearrangement of meso-epoxides
Hodgson,Cameron,Christlieb,Green,Lee,Robinson
, p. 2161 - 2174 (2007/10/03)
Enantioselective α-deprotonation-rearrangement of achiral substituted cyclooctene oxides 7, 27 and 28 and N-Boc hexahydroazonine oxide 45 using organolithiums in the presence of (-)-sparteine 3 or (-)-α-isosparteine 4 gives the functionalised bicyclo[3.3.0]octan-2-ols 9, 29, and 32 and indolizinol 47 in 50-72% yields and 83-89% ees.
A new and enantioselective indolizidine synthesis by meso-epoxide α-deprotonation-transannular N-C insertion
Hodgson, David M.,Robinson, Lesley A.
, p. 309 - 310 (2007/10/03)
Enantioselective α-deprotonation-rearrangement of N-Boc hexahydroazonine oxide 10 using organolithiums in the presence of (-)-sparteine 3 gives the ester 12 in up to 89% ee.
