223926-62-3

Upstream product

• 57246-71-6 methyl pentanimidate 
• 710-11-2 2-oxo-4-phenylbutyric acid 
• 19920-74-2 Valerimidsaeure-(2-formyl-hydrazid) 

Downstream Products

• 223926-75-8 3-butyl-6-phenethyl-2-<2'-(1-trityl-tetrazol-5-yl)-biphenyl-4-ylmethyl>-2H-<1,2,4>triazin-5-one 
• 223926-73-6 3-butyl-6-phenethyl-4-<2'-(1-trityl-tetrazol-5-yl)-biphenyl-4-ylmethyl>-4H-<1,2,4>triazin-5-one 

Relevant academic research and scientific papers

Angiotensin II receptor antagonistic 1,2,4-triazin-5-one derivatives

Disclosed are novel 1,2,4-triazin-5-one biphenyl derivatives having structural formula (I) useful as non-peptide antagonists of angiotensin II receptor: where R1 represents alkyl, cycloalkyl, or substituted or unsubstituted aryl; R2 represents alkyl, substituted or unsubstituted aryl, or arylalkyl; A and D independently represent C-R3, N, NH or C=O, wherein when A and D independently denote C-R3 or N, b and c are independently a double bond, and when A and D independently denote NH or C=O, b and c are independently a single bond; provided that b and c are not both double bonds; and R3 is hydrogen, dialkylphosphonate or halogen; and pharmaceutically acceptable salts thereof. Also disclosed is the use of the compounds of formula (I) as non-peptide antagonists of angiotensin II receptor, in the treatment of cardiovascular diseases, in particular hypertension and congestive heart failure.

The syntheses of triazinone and pyrimidinone biphenyltetrazoles as angiotensin II receptor antagonists

A series of biphenylyltetrazole substituted triazinones and structure-related pyrimidinones are systhesized, and their binding affinities for angiotensin II receptor are reported.