22393-86-8Relevant articles and documents
Zirconocene-catalyzed direct (trans)esterification of acyl acids (esters) and alcohols in a strict 1:1 ratio under solvent-free conditions
Tang, Zhi,Jiang, Qiutao,Peng, Lifen,Xu, Xinhua,Li, Jie,Qiu, Renhua,Au, Chak-Tong
supporting information, p. 5396 - 5402 (2017/11/22)
A highly efficient way for the direct (trans)esterification of acyl acids (esters) and alcohols in a strict 1:1 ratio using a zirconocene complex (1, 1 mol%), a strong Lewis acid of good water tolerance, as a catalyst under solvent-free conditions has been developed. A wide range of acid and alcohol (esters) substrates undergo (trans)esterification to produce carboxylic ester motifs in moderate to good or excellent yields with good functional tolerance, such as that towards C-Br as well as CC and CC bonds. And complex 1 can be recycled six times without showing a significant decline in catalytic efficiency. It was demonstrated that cyclandelate, which is used to treat high blood pressure as well as heart and blood-vessel diseases, can be directly synthesized on a gram scale with 81% yield (6.70 g) using complex 1.
Liquid-liquid biphasic synthesis of long chain wax esters using the Lewis acidic ionic liquid choline chloride·2ZnCl2
Sunitha, Sadula,Kanjilal, Sanjit,Reddy, P. Srinivasa,Prasad, Rachapudi B.N.
, p. 6962 - 6965 (2008/02/13)
The first liquid-liquid biphasic synthesis of wax esters in a Lewis acidic ionic liquid, choline chloride·2ZnCl2 by the esterification of long chain carboxylic acids with long chain alcohols is described. The reported reaction system has the advantages of both homogeneous and heterogeneous catalysis with high product yield and the ease of product as well as catalyst separation without the use of an organic solvent. The ionic liquid studied plays the dual role of solvent as well as catalyst and is recycled up to six times without any significant loss of activity.
Efficient esterification of long chain aliphatic carboxylic acids with alcohols over ZrOCl2·8H2O catalyst
Mantri, Kshudiram,Komura, Kenichi,Sugi, Yoshihiro
, p. 1939 - 1944 (2007/10/03)
Direct condensation of equimolar amounts of long chain carboxylic acids and alcohols could be achieved by using zirconyl chloride as an efficient catalyst. ZrOCl2·SH2O showed high activity for esterification between primary acids and alcohols; however, it was less active in the combination of branched acid and secondary alcohols to give the corresponding esters. Georg Thieme Verlag Stuttgart.