22397-92-8Relevant academic research and scientific papers
(3R)-3-Amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Nitta, Aiko,Fujii, Hideaki,Sakami, Satoshi,Nishimura, Yutaka,Ohyama, Tomofumi,Satoh, Mikiya,Nakaki, Junko,Satoh, Shiho,Inada, Chifumi,Kozono, Hideki,Kumagai, Hiroki,Shimamura, Masahiro,Fukazawa, Tominaga,Kawai, Hideki
scheme or table, p. 5435 - 5438 (2009/05/30)
Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides and 3-amino-N-(4-aryltetrahydropyran-4-yl)butanamides were synthesized and evaluated as dipeptidyl peptidase IV (DPP-IV) inhibitors. Derivatives incorporating the 6-substituted benzothiazole group showed highly potent DPP-IV inhibitory activity. Oral administration of (3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide (12u) reduced blood glucose excursion in an oral glucose tolerance test.
Synthesis and conformational studies of tertiary alcohols derived from tetrahydro-4H-pyran-4-one and tetrahydrothiopyran-4-one
Tran, Kevin,Berlin, K. Darrell,Holt, Elizabeth M.,Hallford, Randal,Eastman, Margaret A.,Yu, Valentina K.,Praliev
, p. 53 - 66 (2007/10/03)
A series of derivatives of tetrahydro-4H-pyran-4-one and tetrahydrothiopyran-4-one have been prepared by condensation with aryl Grignard reagents. IR spectra, 1H and 13C NMR spectral analyses, and elemental analyses support the struc
Stereoselectivity in the Reactions between the Anion of 4-Phenyl-5,6-dihydro-2H-thiopyran 1-Oxide and Electrophiles
Crumbie, Robyn L.,Ridley, Damon D.,Steel, Peter J.
, p. 119 - 132 (2007/10/02)
Treatment of the anion (17), prepared from the six-membered ring allylic sulfoxide 4-phenyl-5,6-dihydro-2H-thiopyran 1-oxide (8) with primary alkyl halides at -78 deg C, affords trans-2-alkyl-4-phenyl-5,6-dihydro-2H-thiopyran 1-oxides exclusively.The ster
