224037-65-4

Upstream product

• 163229-87-6 (E,E)-nonadeca-4,8-dienoic acid ethyl ester 
• 224037-60-9 (4R,5R,8R,9R)-5-mesyloxy-8,9-isopropylidenedioxynonadecan-1,4-olide 
• 185980-35-2 (4R,5R,8R,9R)-5,8,9-trihydroxynonadecan-1,4-olide 
• 224037-47-2 (4R,5S,8R,9R)-9-hydroxy-5,8-oxidononadecan-1,4-olide 
• 185980-34-1 (6E)-heptadeca-1,6-dien-3-ol 
• 163229-88-7 (4R,5R,8R,9R)-5-hydroxy-8,9-isopropylidenedioxynonadecan-1,4-olide 
• 131618-60-5 (trans)-pentadec-4-en-1-al 
• 59101-21-2 (E)-pentadec-4-enoic acid ethyl ester 
• 59101-25-6 trans-pentadec-4-en-1-ol 
• 224037-61-0 (4R,5S,8R,9R)-9-tert-butyldiphenylsilyloxy-5,8-oxidononadecan-1,4-olide 

Downstream Products

• 224037-56-3 (2RS)-2-thiophenoxy-2,35:12,13:12,13-hexahydrotrilobin-bis(methoxymethoxy) ether 
• 224037-57-4 (2RS)-2-thiophenoxy-2,35-didehydrotrilobin-bis(methoxymethoxy) ether 
• 224037-52-9 (4R,5R,8R,9S,12R,13R)-1-trimethylsilyl-13-tert-butyldiphenylsilyloxy-5,8:9,12-dioxidotricos-1-yn-4-ol 
• 224037-49-4 (E,6R,7S,10R,11R)-11-tert-butyldiphenylsilyloxy-7,10-oxidoheneicos-2-en-1,6-diol 
• 224037-51-8 (2R,3R,6R,7S,10R,11R)-11-tert-butyldiphenylsilyloxy-1,2:3,6:7,10-trioxidoheneicosane 

Relevant academic research and scientific papers

Total synthesis of trilobin

The first total synthesis of (+)-trilobin (1a) was achieved in 22 steps and 2.74% yield by means of the 'naked' carbon skeleton strategy, with all of the asymmetric centers in the bis-THF fragment of the molecules being produced by the Sharpless asymmetric dihydroxylation and the asymmetric epoxidation reactions. The synthetic Scheme represents a general methodology for the preparation of trans,cis-bis-THF ring systems.