224040-86-2

Usage

Uses

Used in Chemical Research:
Ethanone, 1-(2-naphthalenyl)-2-(4-pyridinyl)is used as a ligand in coordination chemistry for its ability to form stable complexes with metal ions, which is crucial for various chemical research applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Ethanone, 1-(2-naphthalenyl)-2-(4-pyridinyl)is used as a bidentate chelating agent for the synthesis of metal complexes with potential therapeutic properties.
Used in Organic Synthesis:
Ethanone, 1-(2-naphthalenyl)-2-(4-pyridinyl)is utilized in organic synthesis for the creation of new compounds and the modification of existing ones, thanks to its ability to chelate with metal ions and influence the reactivity and selectivity of reactions.

Upstream product

• 93-09-4 naphthalene-2-carboxylate 
• 2243-83-6 2-naphthaloyl chloride 
• 108-89-4 picoline 
• 113443-62-2 N-methoxy-N-methylnaphthalene-2-carboxamide 

Downstream Products

• 629623-78-5 6-naphthalen-2-yl-5-pyridin-4-yl-pyridazin-3-ol 

Relevant academic research and scientific papers

MAP KINASE MODULATORS AND USES THEREOF

The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38a MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising adm

Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement

In this Letter, we describe the evolution of selective JNK3 inhibitors from 1, that routinely exhibit >10-fold selectivity over JNK1 and >1000-fold selectivity over related MAPKs. Strong SAR was found for substitution of the naphthalene ring, as well as f

Pyridinylimidazole inhibitors of Tie2 kinase

This communication details the evolution of the screening lead SB-203580, a known CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase inhibitor. The optimized compound 5 showed efficacy in an in vivo model of angiogenesis and a MOP

Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase

Novel potent trisubstituted pyridazine inhibitors of p38 MAP (mitogen activated protein) kinase are described that have activity in both cell-based assays of cytokine release and animal models of rheumatoid arthritis. They demonstrated potent inhibition o

SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE

The present invention relates to compounds having the general formula (I) or a pharmaceutically acceptable salt thereof, wherein Rl is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R1 is additionally substituted; and R2 is a substituted C1-6balkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

Adenosine A3 receptor antagonists

A pharmaceutical composition for antagonizing adenosine at adenosine A3receptors which comprises a 1,3-azole compound substituted on the 4- or 5-position, or both, by a pyridyl which may be substituted is provided and can be used as a prophylactic and therapeutic agent for asthma, allergosis, inflammation, and so on.