224044-63-7

Upstream product

• 224044-61-5 2-bromo-1-(2-nitro-3-phenylmethoxyphenyl)ethanone 
• 224044-60-4 2-nitro-3-benzyloxyacetophenone 
• 224044-62-6 diethyl (acetylamino)<2-(2-nitro-3-phenylmethoxyphenyl)-2-oxoethyl>propanedioate 

Downstream Products

• 224044-64-8 diethyl (acetylamino)<2-<2-nitro-3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)oxyphenyl>-2-oxoethyl>propanedioate 
• 224044-65-9 diethyl (acetylamino)<2-<2-amino-3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)oxyphenyl>-2-oxoethyl>propanedioate 

Relevant academic research and scientific papers

Synthesis of Human Ultraviolet Filter Compounds: O-β-D-Glucopyranosides of 3-Hydroxykynurenine and 2-Amino-3-hydroxy-γ-oxobenzenebutanoic Acid

The role of endogenous tryptophan-derived UV filters in aging lenses and in human cataract is becoming increasingly important. The two major UV filters found in the lenses of primates, the O-β-D-glucopyranosides of 3-hydroxykynurenine and 2-amino-3-hydroxy-γ-oxobenzenebutanoic acid, 1 and 2, were synthesized from the common benzoyl acrylate precursor 2-amino-3-hydroxybenzoyl-acrylic acid 10. Synthesis of compound 3, the α-N-acetyl derivative of 1, was achieved using coupling of 2-nitro-3-benzyloxyacetophenone 4 with the sodium salt of diethyl acetamidomalonate as a key step. This is the first reported synthesis of the lenticular glucopyranoside 2 and the N-acetyl compound 3.