22408-61-3Relevant articles and documents
Synthesis and structure of novel 3,4-annelated coumarin derivatives
Deki?, Milan S.,Deki?, Biljana R.,Deki?, Vidoslav S.,Deki?, Stojadin V.
, p. 295 - 297 (2008)
(Chemical Equation Presented) Condensation of 4-chloro-2-oxo-2H-chromene-3- carbonitrile (1) with heteroarylamines 2a-d in acetonitrile containing a catalytic amount of triethylamine followed by spontaneous intramolecular cyclization gave the novel coumarin derivatives 3a-d, respectively. These compounds underwent acid hydrolysis giving the corresponding oxoderivatives 4a-d. The structural assignments of the synthesized compounds were based on elemental, IR, 1H and 13C NMR analyses.
An efficient route for synthesis and reactions of seleno[2, 3-c]coumarin
Abdel-Hafez, Shams H.,Elkhateeb, Ahmed,Gobouri, Adel A.,El Azab, Islam H.,Kirsch, Gilbert
, p. 1054 - 1062 (2016)
Synthesis of new selenium-containing coumarin moiety via the reaction of 4-chloro-2-oxo-2H-chromene-3-carbonitrile with selenium and sodium borohydride gave 3-cyano-4-coumarinselenol which reacted with different halo-acids, such as chloroacetonitrile, eth
Synthesis and antimicrobial activity of new heterocyclic compounds containing thieno[3,2-c]coumarin and pyrazolo[4,3-c]coumarin frameworks
El-Dean, Adel M. Kamal,Zaki, Remon M.,Geies, Ahmed A.,Radwan, Shaban M.,Tolba, Mahmoud S.
, p. 553 - 564 (2013)
Reaction of 4-chlorocoumarin-3-carbonitrile with ethyl thioglycolate and ethyl glycinate hydrochloride leads to a series of title products. Hydrazinolysis of amino thienocoumarin carboxylate afforded the hydrazino derivative which underwent various reactions to build new heterocyclic rings containing thienocoumarin moiety. Chloro acetylation of aminoester compound afforded the chloro acetyl amino which underwent nucleophilic substitution reactions with various amines. The following treatment with formaldehyde under Mannich conditions afforded the corresponding imidazo derivatives. Reaction of chloroacetylamino with potassium thiocyanate yielded ethylpyrimidothieno coumarin sulfanylacetate which was used as a versatile precursor for synthesis of other heterocycles. On the other hand, reaction of chloro coumarin carbonitrile with hydrazine gave the aminopyrazolocoumaine which reacted with bifunctionally compounds to give the substituted pyrimido derivatives. Diazotization and coupling of aminopyrazole with ethylcyanoacetate yielded ethylaminotriazinopyrazolocoumarine carboxylate. Several of the compounds obtained demonstrated considerable antifungal and antibacterial activity in the in vitro test systems.
