224183-87-3

Upstream product

• 917-57-7 vinyllithium 
• 224183-82-8 methyl 2-methyl-3-(methoxymethoxy)-6-(methoxycarbonyl)-2H,3H,4H-azinecarboxylate 
• 1112-56-7 tetravinyltin (IV) 
• 224183-80-6 methyl 6-[(trifluoromethyl)sulfonyloxy]-2-methyl-3-(methoxymethoxy)-2H,3H,4H-azinecarboxylate 
• 224183-76-0 methyl 6-methyl-5-(methoxymethoxy)-2-oxopiperidinecarboxylate 
• 224184-14-9 (5S,6S)-5-Methoxymethoxy-6-methyl-piperidin-2-one 
• 165672-51-5 (5S,6S)-1-Benzyl-5-methoxymethoxy-6-methyl-piperidin-2-one 

Downstream Products

• 224184-08-1 methyl 2-aza-3-methyl-4-(methoxymethoxy)-7-[(phenylsulfonyl)methyl]bicyclo[4.4.0]decane-2-carboxylate 
• 224184-06-9 methyl 2-aza-3-methyl-4-(methoxymethoxy)-9-oxo-7-[(phenylsulfonyl)methyl]bicyclo[4.4.0]decane-2-carboxylate 
• 224184-10-5 tert-butyl 2-aza-3-methyl-4-(methoxymethoxy)-7-[(phenylsulfonyl)methyl]bicyclo[4.4.0]decane-2-carboxylate 
• 224184-04-7 methyl 2-aza-3-methyl-4-(methoxymethoxy)-9-oxo-7-[(phenylsulfonyl)phenylthiomethyl]bicyclo[4.4.0]decane-2-carboxylate 

Relevant academic research and scientific papers

Construction of 4a,8a-cis-octahydroquinolin-7-one core using an intramolecular aldol type of cyclization: An application to enantioselective total synthesis of lepadin B

An intramolecular aldol type of cyclization of the piperidine derivative 1 proceeded in highly stereoselective manner to afford the desired 4a,8a-cis- octahydroquinolin-7-one. This key step involves a feature of the use of A((1.3)) strain as a control element, in biasing 1 towards the conformer desired for the above cyclization. An application of this aldol reaction to enantioselective total synthesis of the marine alkaloid lepadin B is also described.