224184-18-3Relevant academic research and scientific papers
The design of non-peptide human Bradykinin B2 receptor antagonists employing the benzodiazepine peptidomimetic scaffold
Dziadulewicz, Edward K.,Brown, Michael C.,Dunstan, Andrew R.,Lee, Wai,Said, Najeeb B.,Garratt, Peter J.
, p. 463 - 468 (2007/10/03)
The Bradykinin B2 receptor antagonist HOE 140 (D-Arg-Arg-Pro-Hyp-Gly- Thi-Ser-D-Tic-Oic-Arg) has been used as a template for the de novo design and synthesis of a small number of non-peptide lead compounds based on the 1,4- benzodiazepin-2-one framework. Two of the compounds have been found to exhibit moderate K(i) values of 8.9 and 9.2 μM at the human Bradykinin B2 receptor.
