22419-86-9

Basic information

• Product Name: (3R)-6,9-bis-methylene-(3rN,3at,6at,9at,9bc)-Δ^1'-dodecahydro-spiro[azuleno[4,5-b]furan-3,3'-pyrazol]-2-one
• CAS NO: 22419-86-9
• Molecular Weight: 272.347
• Mol File: 22419-86-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R)-6,9-bis-methylene-(3rN,3at,6at,9at,9bc)-Δ^1'-dodecahydro-spiro[azuleno[4,5-b]furan-3,3'-pyrazol]-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-6,9-bis-methylene-(3rN,3at,6at,9at,9bc)-Δ^1'-dodecahydro-spiro[azuleno[4,5-b]furan-3,3'-pyrazol]-2-one(22419-86-9)
• EPA Substance Registry System: (3R)-6,9-bis-methylene-(3rN,3at,6at,9at,9bc)-Δ^1'-dodecahydro-spiro[azuleno[4,5-b]furan-3,3'-pyrazol]-2-one(22419-86-9)

Safety Data

• Hazardous Substances Data: 22419-86-9(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 74299-48-2 dehydrocostus lactone 

Relevant articles and documents

11,13-METHYLENATION OF SESQUITERPENE EXOMETHYLENE-&γ-LACTONES: SYNTHESIS OF SESQUITERPENE CYCLOPROPYL-&γ-LACTONES

11,13-Methylene derivatives of sesquiterpene exomethylene-γ-lactones were prepared by reaction of diazomethane and photolysis of the resulting pyrazoline adduct(s).Variable amounts of exomethylene- and ethylidene-γ-lactones were also formed in the photolysis reaction.These compounds could be removed after reaction with diethylamine and chromatography on a bilayer (basic alumina/silica gel) column.Also 11,13-methylene derivatives of acid- and thermolabile germacranolides could be prepared in good yield with this procedure.Results obtained using alternative methods of methylenation are reported.A comparative study of the reactivity towards nucleophiles of exomethylene- and cyclopropyl sesquiterpene-γ-lactones provided little support for the involvement of compounds of the latter class in "in vivo" alkylation reactions.