22421-56-3

Basic information

• Product Name: [(o-bromophenoxy)methyl]oxirane
• Synonyms: [(o-bromophenoxy)methyl]oxirane;2-Bromophenylglycidyl ether
• CAS NO: 22421-56-3
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.07056
• EINECS: 244-985-7
• Mol File: 22421-56-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 289.6°Cat760mmHg
• Flash Point: 133.5°C
• Appearance: /
• Density: 1.527g/cm³
• Vapor Pressure: 0.00379mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: [(o-bromophenoxy)methyl]oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: [(o-bromophenoxy)methyl]oxirane(22421-56-3)
• EPA Substance Registry System: [(o-bromophenoxy)methyl]oxirane(22421-56-3)

Safety Data

• Hazardous Substances Data: 22421-56-3(Hazardous Substances Data)

Usage

General Description

[(o-bromophenoxy)methyl]oxirane is a chemical compound that is also known as epichlorohydrin. It is a colorless liquid with a chloroform-like odor, and it is used in the production of epoxy resins, which are commonly used in adhesives, coatings, and plastics. Epichlorohydrin is also used as an intermediate in the synthesis of other chemicals, such as glycerol and pharmaceuticals. However, it is considered to be a hazardous chemical, as it is highly reactive and can cause irritation of the skin, eyes, and respiratory system. It is also classified as a potential carcinogen and mutagen, and precautions should be taken when handling and using this chemical.

InChI:InChI=1/C9H9BrO2/c10-8-3-1-2-4-9(8)12-6-7-5-11-7/h1-4,7H,5-6H2

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 106-89-8 epichlorohydrin 

Downstream Products

• 64463-90-7 1-(2-Bromo-phenoxy)-3-(2-phenoxy-ethylamino)-propan-2-ol 
• 56215-82-8 1-(2-Bromo-phenoxy)-3-(3-ethylsulfanyl-propylamino)-propan-2-ol 
• 63834-58-2 rac-3-(2-bromophenoxy)propane-1,2-diol 
• 431882-86-9 3-(3'-(2''-bromophenoxy)-2'-hydroxypropyl)-5,5-dimethylimidazolidine-2,4-dione 
• 1009167-24-1 C₁₅H₂₂BrNO₃ 
• 122-60-1 Phenyl glycidyl ether 
• 140428-44-0 1-bromo-3-phenoxy-propan-2-ol 
• 21834-60-6 3,4-dihydro-2H-1-benzopyran-3-ol 
• 68224-03-3 (2,3-dihydro-benzofuran-3-yl)methanol 
• 100794-31-8 1-(2-bromo-phenoxy)-3-piperidino-propan-2-ol 

Relevant articles and documents

Substituted diaryl compound and preparation method and application thereof

The invention relates to the field of medicinal chemistry, in particular to a substituted diaryl compound (I). The preparation method comprises the following steps: medicine preparation and medical application thereof. Test results show that the substituted diaryl compound has a good inhibition effect on human lung cancer (A549), human ovarian cancer (SKOV3), human melanoma (A375) and human colon cancer (LOVO) cells. Formula (I):

Chelation-directed remote: Meta -C-H functionalization of aromatic aldehydes and ketones

We disclose herein the development of a versatile 1,2-diol directing template for palladium-catalyzed remote meta-C-H functionalization of aromatic aldehydes and ketones. In situ-generation of acetals and ketals, as well as removal afterwards, makes the C-H bond functionalization process more straightforward and efficient. This also represents the first example of chelation-directed meta-C-H functionalization of aromatic aldehydes and ketones.

Dual catalysis by Cu(i): Facile single step click and intramolecular C-O bond formation leading to triazole tethered dihydrobenzodioxines/benzoxazines/ benzoxathiines/benzodioxepines

Dual copper catalysis, involving two different reactions, click (alkyne-azide) and carbon-oxygen bond formation (aryl iodide-secondary alcohol) in a single step, is reported. Synthesis of novel benzodioxines (benzodioxanes), benzoxazines, benzoxathiines and benzodioxepines, which feature benzo-condensed six or seven membered rings containing two hetero-atoms attached to a 1,2,3-triazole, is described. As an extension, such compounds were also synthesised by ring opening of epoxide and cyclisation using Cu(i). All the key products have been characterized by single crystal X-ray crystallography.