224309-29-9Relevant academic research and scientific papers
Structure-based design of diaminopyranosides as a novel inhibitor core unit of HIV proteases
Kurihara, Shinwa,Tsumuraya, Takeshi,Fujii, Ikuo
, p. 1179 - 1184 (2007/10/03)
Novel HIV PR inhibitors, which contain a diaminopyranoside moiety as an inhibitor core unit, were designed based on the 3D structures of complexes of HIV-1 PR with transition-state mimics. These compounds were examined for their ability to inhibit the hydrolytic activity of a recombinant HIV-1 PR.
