22441-87-8Relevant academic research and scientific papers
In Situ Generation of a Regio- and Diastereoselective Hydroaminoalkylation Catalyst Using Commercially Available Starting Materials
Edwards, Peter M.,Schafer, Laurel L.
supporting information, p. 5720 - 5723 (2017/11/10)
The design of an easy to use catalyst system for the regio- and diastereoselective intermolecular hydroaminoalkylation of alkenes with secondary amines is reported. The method utilizes commercially available ligands and tantalum starting materials, and does not require the isolation of air and water sensitive organometallic complexes. The in situ prepared catalyst is active toward a variety of secondary amine substrates, including those with ethyl substituents which yield α- and β-alkylated amines as a single diastereomer. This catalytic transformation can be used to prepare amines containing functionality that promotes ring closure to achieve the diastereoselective synthesis of di- and trialkylated N-heterocycles.
Aminopyridinato titanium catalysts for the hydroaminoalkylation of alkenes and styrenes
Doerfler, Jaika,Doye, Sven
supporting information, p. 1806 - 1809 (2013/04/10)
The linear product is formed as the major product when in situ generated titanium complexes with aminopyridinato ligands are used as catalysts for hydroaminoalkylation reactions of styrenes (see scheme). The reaction is not limited to the use of N-methyla
