22454-86-0

Basic information

• Product Name: CALCIUM OROTATE
• Synonyms: CALCIUM OROTATE;OROTIC ACID CALCIUM SALT;calcium 1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylate;calcium oratate;Calciumorotatehadrate;Oroticacidcalciumsalthydrate;Uracil-6-carboxylic acid calcium salt;4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-, calcium salt (2:1)
• CAS NO: 22454-86-0
• Molecular Formula: C₅H₂N₂O₄*Ca
• Molecular Weight: 368.27
• EINECS: 245-009-2
• Mol File: 22454-86-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Aqueous Base (Slightly), DMSO (Slightly)
• CAS DataBase Reference: CALCIUM OROTATE(CAS DataBase Reference)
• NIST Chemistry Reference: CALCIUM OROTATE(22454-86-0)
• EPA Substance Registry System: CALCIUM OROTATE(22454-86-0)

Safety Data

• Hazardous Substances Data: 22454-86-0(Hazardous Substances Data)

Usage

General Description

Calcium orotate is a mineral supplement that provides a source of calcium, an essential mineral for bone health, muscle function, and nerve function. Orotic acid is a natural substance that is found in the body and is believed to enhance the delivery of calcium to the cells. When combined with calcium, orotic acid is believed to improve the absorption and utilization of calcium in the body. Calcium orotate is commonly used as a dietary supplement to support bone health, reduce the risk of osteoporosis, and promote overall wellness. It is available in various forms, including capsules, tablets, and powders, and is generally well-tolerated with few reported side effects.

InChI:InChI=1/2C5H4N2O4.Ca/c2*8-3-1-2(4(9)10)6-5(11)7-3;/h2*1H,(H,9,10)(H2,6,7,8,11);/q;;+2/p-2

Synthetic route

orotic acid (65-86-1) → calcium orotate (22454-86-0)

Conditions	Yield
With ammonium hydroxide; calcium chloride at 80℃; for 24h;	23%

Upstream product

• 65-86-1 orotic acid 

Relevant articles and documents

Orotate Complexes, II. Preparation and Crystal Structures of Calcium and Zinc Orotate(2-) Hydrates

From aqueous solutions containing orotate (dianion of 1) and calcium or zinc ions in the molar ratio of 2:1, metal orotate(2-) hydrates are readily obtained in crystalline form at pH 9.0 and 5.4, respectively.According to an X-ray crystal structure analysis, calcium orotate tetrahydrate forms a one-dimensional coordination polymer with each orotate ligand coordinated to no less than three neighboring calcium atoms.In this cation triple, the orotate(2-) anion acts as a carboxylate-O/amide-N-chelating group for the central calcium ion, but also as a carboxylate-O/O-chelating group for the first neighboring calcium ion, and as a terminal amide-O donor for the second.Each calcium ion is thus octacoordinated and linked to three orotate(2-) anions and three water molecules.The fourth water molecule is only engaged in hydrogen bonding.The new zinc orotate(2-) phase features Zn(Or)(H2O)4 units.For the hexacoordinate zinc atom bearing four water molecules the orotate(2-) ligand also acts as an O/N-chelating group.Unlike a discrete Zn(Or)(H2O)4*H2O phase reported earlier, the lattice of the new phase contains further disordered water of crystallization, with the overall composition approaching Zn(Or)*5,5H2O.The apparent stability of the M(Or) units probably reflects the well-documented carrier function of the orotate ligand for certain divalent metal ions in biological systems.Key Words: Orotate complexes / Calcium complexes / Zinc complexes