224568-13-2

Basic information

• Product Name: Linolenic-1-13C Acid
• Synonyms: Linolenic-1-13C Acid;DTOSIQBPPRVQHS-JAYTYYOISA-N
• CAS NO: 224568-13-2
• Molecular Formula: C18H30O2
• Molecular Weight: 279.4386
• Mol File: 224568-13-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Amber Vial, Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Linolenic-1-13C Acid(CAS DataBase Reference)
• NIST Chemistry Reference: Linolenic-1-13C Acid(224568-13-2)
• EPA Substance Registry System: Linolenic-1-13C Acid(224568-13-2)

Safety Data

• Hazardous Substances Data: 224568-13-2(Hazardous Substances Data)

Usage

Uses

Linolenic-1-13C Acid is labelled Linolenic Acid (L467650) which is an essential fatty acid. Occurs as the glyceride in most drying oils.

Upstream product

• 463-40-1 (9Z,12Z,15Z)-octadeca-9-12,15-trienoic acid 
• 59044-29-0 cis,cis,cis-9,12,15-octadecatrienoyl chloride 

Relevant articles and documents

Large-scale preparation of (9Z,12E)-[1-13C]-octadeca-9,12-dienoic acid, (9Z,12Z,15E)-[1-13C]-octadeca-9,12,15-trienoic acid and their [1-13C] all-cis isomers

Several grams of labelled trans linoleic and linolenic acids with high chemical and isomeric purities (>97%) have been prepared for human metabolism studies. A total of 12.5 g of (9Z,12E)-[1-13C]-octadeca-9,12-dienoic acid and 6.3 g of (9Z,12Z,15E)-[1-13C]-octadeca-9,12,15-trienoic acid were obtained in, respectively, seven steps (7.8% overall yield) and 11 steps (7% overall yield) from 7-bromo-heptan-1-ol. The trans bromo precursors used for the labelling were synthesised by using copper-catalysed couplings. The trans fatty acids were then obtained via the nitrile derivatives. A total of 23.5 g of (9Z,12Z)-[1-13C]-octadeca-9,12-dienoic acid and 10.4 g of (9Z,12Z,15Z)-[1-13C]-octadeca-9,12,15-trienoic acid were prepared in five steps in, respectively, 32 and 18% overall yield. Large quantities of bromo and chloro precursors were synthesised from the commercially available acid according to Barton's procedure. In all cases, the main impurities (>0.5%) of each labelled fatty acid have been characterised. Copyright (C) 2000 Elsevier Science Ireland Ltd.