224585-45-9Relevant articles and documents
Identification of a novel, orally bioavailable histamine H3 receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template
Aslanian, Robert,Mutahi, Mwangi W.,Shih, Neng-Yang,McCormick, Kevin D.,Piwinski, John J.,Ting, Pauline C.,Albanese, Margaret M.,Berlin, Michael Y.,Zhu, Xiaohong,Wong, Shing-Chun,Rosenblum, Stuart B.,Jiang, Yueheng,West, Robert,She, Susan,Williams, Shirley M.,Bryant, Matthew,Hey, John A.
, p. 937 - 941 (2007/10/03)
A novel series of histamine H3 receptor antagonists, based on the 4-benzyl-(1H-imidazole-4-yl) template, incorporating urea and carbamate linkers has been prepared. Compound 3j is a selective H3 antagonist and demonstrates excellent