2246-42-6

Usage

Uses

Used in Pharmaceutical Industry:
2-methoxynaphthalen-1-amine is used as a chemical intermediate for the synthesis of various pharmaceuticals, leveraging its structural properties and reactivity in chemical reactions to create a range of medicinal compounds.
Used in Agrochemical Industry:
2-methoxynaphthalen-1-amine is used as an intermediate in the manufacture of pesticide and herbicide products, contributing to the development of effective agricultural solutions.
Used in Chemical Industry:
2-methoxynaphthalen-1-amine is used as a precursor for the production of dyes and pigments, enabling the creation of a variety of colorants for different applications.
Used in Research and Development:
2-methoxynaphthalen-1-amine has potential applications in the field of medicinal chemistry due to its structural properties and reactivity, making it a valuable compound for research and development in chemical and pharmaceutical innovation.

InChI:InChI=1/C11H11NO/c1-13-10-7-6-8-4-2-3-5-9(8)11(10)12/h2-7H,12H2,1H3

Upstream product

• 4900-66-7 2-methoxy-1-nitronaphthalene 
• 3401-47-6 1-bromo-2-methoxynaphthalene 
• 13101-92-3 1-chloro-2-methoxynaphthalene 
• 57-13-6 urea 
• 2036-46-6 1-phenylazo-2-methoxynaphthalene 
• 67-56-1 methanol 
• 20937-86-4 2-azidonaphthalene 
• 139979-07-0 (2-Methoxy-naphthalen-1-yl)-carbamic acid ethyl ester 
• 64-19-7 acetic acid 
• 7647-01-0 hydrogenchloride 
• 77262-83-0 1-(2-methoxyphenylazo)-2-methoxynaphthalene 
• 64-17-5 ethanol 
• 77262-88-5 1-(4-methylphenylazo)-2-methoxynaphthalene 
• 77262-87-4 1-(3-methylphenylazo)-2-methoxynaphthalene 

Downstream Products

• 85-04-1 N-(2-methoxy-[1]naphthyl)-acetamide 
• 108979-03-9 (2-methoxynaphthalen-1-yl)(phenyl)sulfane 
• 874514-06-4 N-(2-methoxy-[1]naphthyl)-toluene-4-sulfonamide 
• 1888-41-1 2-methoxy-1-naphthol 
• 239-01-0 11H-benzo[a]carbazole 
• 859495-62-8 N-(4-bromo-2-methoxy-[1]naphthyl)-toluene-4-sulfonamide 
• 101732-30-3 N-(2-methoxy-4-nitro-[1]naphthyl)-toluene-4-sulfonamide 
• 108980-58-1 1-benzenesulfonyl-2-methoxy-naphthalene 
• 14847-35-9 2-Oxo-2,3-dihydro-1H-naphtho<2,1-b><1,4>oxazine 
• 83710-61-6 1-bromo-7-methoxy-naphthalene 

Relevant academic research and scientific papers

ION CHANNEL ANTAGONISTS/BLOCKERS AND USES THEREOF

Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.

Synthesis of sterically congested 1,5-disubstituted-1,2,3-Triazoles using chloromagnesium acetylides and hindered 1-naphthyl azides

Sterically congested 1-(2-methoxy-1-naphthyl)-5-substituted-1,2,3-triazoles can be prepared from sterically hindered 2-methoxy-1-azidonaphthalene and chloromagnesium acetylides, including 2-substituted phenylacetylides. Catalytic methods using Cp?RuCl(PPh

PYRIDONE-PYRIMIDINE DERIVATIVE ACTING AS KRASG12C MUTEIN INHIBITOR

Provided are a class of KRAS G12C mutein inhibitors, which relate in particular to a compound represented by formula (I), an isomer thereof, and a pharmaceutically acceptable salt thereof.

Metal-free Semiconductor Photocatalysis for sp2 C?H Functionalization with Molecular Oxygen

Designing metal-free catalysts for solar energy conversion is a long-standing challenge in semiconductor photoredox catalysis (SPC). With visible-light-responsive hexagonal boron carbon nitride (h-BCN) as a non-metal photocatalyst, this system affords C?H/N?H coupling products with broad substitution tolerance and high efficiency with molecular oxygen as the terminal oxidant. The catalyst exhibits remarkable performance for the selective C?H functionalization of electron-rich arenes to C?N products (yields up to 95 %) and good stability (6 recycles). Both nitrogen heteroarenes and amine salts are competent coupling nucleophiles. Mechanically, the reactive oxygen species are superoxide anion radical (O2?.) and H2O2, which are proved by electron spin resonance (ESR) data, KI-starch, and control experiments. In addition, kinetic isotope effect (KIE) experiments indicate that C?H bond cleavage is not involved in the rate limiting step. This semiconductor-based photoredox system allows for C?H amination free of any metals, ligands, strong oxidants, and additives. It provides a complementary avenue to C?H functionalizations and enables synthetic applications efficiently in a sustainable manner.

Cu(II)-Mediated N-H and N-Alkyl Aryl Amination and Olefin Aziridination

Cu(II)-mediated direct NH2 and NH alkyl aryl aminations and olefin aziridinations are described. These room-temperature, one-pot, environmentally friendly procedures replace costly Rh2 catalysts and, in some instances, display important differences with comparable Rh2- and Fe-supported reactions.

Method of preparing arylamine by photo-catalyzing C-H activation with semiconductor

The invention discloses a method of preparing arylamine by photo-catalyzing C-H activation with a semiconductor. The method comprises the following steps of by taking an aromatic compound as a substrate and boron-nitrogen-carbon as a photocatalyst, adding an amino source, a solvent and alkali, performing stirring reaction for 48h under the condition of visible light radiation at room temperature in an oxygen atmosphere, and synthesizing an arylamine compound. The boron-nitrogen-carbon (h-BCN) is a semiconductor polymer photocatalyst which responds to visible light and does not contain metallicelements and has the advantages of low cost, availability, good chemical stability, non toxicity, innocuousness, proper forbidden band width and energy band position and the like. The catalyst is used for synthesizing the arylamine compound, is simple in operation in reaction process, is performed under the visible light, is mild in condition and good in catalytic effect and has the yield, to a target product, reaching 72 percent. The method provided by the invention is simple in technology and low in cost, accords with the actual production needs and has relatively large application potential.

Exploring the Catalytic Reactivity of Nickel Phosphine-Phosphite Complexes

In this study, we present an investigation into various nickel phosphite and phosphite-phosphine complexes for use in the Mizoroki-Heck and Suzuki-Miyaura cross-coupling reactions and the ammonia arylation reaction. In these coupling reactions, it was discovered that the Ni[P(OEt)3]4, (dppf)Ni[P(OPh)3]2, and (binap)Ni[P(OPh)3]2 catalysts were the most effective. In addition, an optimisation process for these catalytic systems as well as functional group compatibility are discussed.

Monna, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1

Transmembrane protein with unknown function 16/anoctamin-1 (ANO1) is a protein widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiological functions. However, the lack of effective and selective blockers has hindered a detailed study of the physiological functions of this channel. In this study, we have developed a potent and selective blocker for endogenous ANO1 in Xenopus laevis oocytes (xANO1) using a drug screening method we previously established (Oh et al., 2008). We have synthesized a number of anthranilic acid derivatives and have determined the correlation between biological activity and the nature and position of substituents in these derived compounds. A structure-activity relationship revealed novel chemical classes of xANO1 blockers. The derivatives contain a-NO2 group on position 5 of a naphthyl group-substituted anthranilic acid, and they fully blocked xANO1 chloride currents with an IC 5050 of 0.08 μM for xANO1. Selectivity tests revealed that other chloride channels such as bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator were not appreciably blocked by 10～30 μM MONNA. The potent and selective blockers for ANO1 identified here should permit pharmacological dissection of ANO1/CaCC function and serve as potential candidates for drug therapy of related diseases such as hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.

Synthesis and characterization of novel starburst phase transfer catalyst

A new phase transfer catalyst, 3,5-bis[(2-methyl-naphthylene-1 -yl)-phenylamino-phenyl]-butyl-(2methoxy-naphthalene-1 -yl)-phenylammonium bromide (BPBPB) has been synthesized, characterized using spectral analysis and its catalytic activity ascertained. Efficiency of BPBPB is studied using etherification of phenol and compared with tetra butyl ammonium bromide (TBAB). O-Alkylation of naphthol, iV-alkylation of indole and halogen substitution reactions are carried out using BPBPB and its efficiency is compared with reported PTCs. BPBPB gives high yield of product, the time for completion of the reaction is short and is required in a very low concentration. Almost 95% of this catalyst is regenerated and reused.

Synthesis and characterisation of hole transporting materials based on N,N,N-tris-[4-(naphthalen-1-yl-phenylamino)phenyl]-N,N,N-triphenylbenzene-1,3, 5-triamine

Two derivatives of star shaped compounds based on naphthylamine with symmetric trisubstituted benzene as core, methoxy and ethoxy as end substitutions are synthesized. The synthesized compounds are characterized by UV-visible, FT-IR and NMR spectrometric techniques. The electronic and thermal properties of the compounds are studied using cyclic voltametry (CV) and differential scanning calorimetry (DSC) respectively. The data's obtained have similarity with the arylamines that have been already used in optoelectronic devices. So these compounds are interesting materials for applications in such devices.