22462-93-7

Upstream product

• 519-66-4 4-hydroxy-1-methyl-3-phenylquinolin-2-one 
• 592-22-3 diacetyl disulfide 
• 144603-33-8 3-chloro-1-methyl-3-phenylquinoline-2,4(1H,3H)-dione 
• 10387-40-3 potassium thioacetate 
• 108-24-7 acetic anhydride 
• 521980-39-2 1-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydroquinolin-3-yl thiocyanate 
• 401635-58-3 3-bromo-1-methyl-3-phenylquinoline-2,4(1H,3H)-dione 

Relevant academic research and scientific papers

1-Methyl-3-phenyl-3-thiocyanato-1H,3H-quinoline-2,4-dione: A Novel Thiocyanating Agent

Under mild reaction conditions, the thiocyanato group is selectively transferred from 1-methyl-3-phenyl-3-thiocyanato-1H,3H-quinoline-2,4-dione (3) to some nucleophiles. Aliphatic primary and secondary amines are converted to S-cyanothiohydroxylamines, anilines afford p-thiocyanatoanilines, Wittig reagent is thiocyanated in α-position, and thiols are oxidized to disulfides.

Synthesis of 3-thiocyanato-1H,3H-quinoline-2,4-diones

4-Hydroxy-1H-quinolin-2-ones (1) react with thiocyanogen in acetic acid to the corresponding 3-thiocyanato-1H,3H-quinoline-2,4-diones (2) in good yields. In some cases, 3-bromo-1H,3H-quinoline-2,4-diones (4) were isolated as minor reaction products. Compo