224635-64-7Relevant academic research and scientific papers
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine
Luo, Weiming,Yu, Qian-Sheng,Zhan, Ming,Parrish, Damon,Deschamps, Jeffrey R.,Kulkarni, Santosh S.,Holloway, Harold W.,Alley, George M.,Lahiri, Debomoy K.,Brossi, Arnold,Greig, Nigel H.
, p. 986 - 994 (2005)
Reductive cyclization of 5-hydroxy-3-methyl-3- methoxycarbonylmethylenebenzofuran-2(3H)-one (4) gave 5-hydroxy-3a-methyl-2,3, 3a,8a-tatrahydrofuro[2,3-6]benzofuran (5) and the rearrangement product 7-hydroxy-4,5-dihydro-2,5-methano-1,3-benzodioxepine (6).
TRICYCLIC COMPOUNDS, PREPARATION THEREOF AND USE THEREOF AS CHOLINESTERASE ACTIVITY INHIBITORS
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Page/Page column 24-25, (2010/11/08)
Described herein are tricyclic compounds of formula (I) and (II) and methods of making them and using them as cholinesterase activity inhibitors.
Syntheses of tetrahydrofurobenzofurans and dihydromethanobenzodioxepines from 5-hydroxy-3-methyl-3H-benzofuran-2-one. Rearrangement and ring expansion under reductive conditions on treatment with hydrides
Luo, Weiming,Yu, Qian-Sheng,Holloway, Harold W.,Parrish, Damon,Greig, Nigel H.,Brossi, Arnold
, p. 6171 - 6176 (2007/10/03)
5-Hydroxy-3-methyl-3H-benzofuran-2-one, 5, easily obtained from pyruvic acid and 1,4-cyclohexanedione, was used as a starting material to prepare (±)-5-hydroxy-3a-methyl-2,3,3a,8a-tetrahydrofuro[2,3-b]benzofuran, 10, and(±)-7-hydroxy-5-methyl-4,5-dihydro-
Synthesis of 5-hydroxyoxaindan-2-ones and indol-5-ols from 1,4- cyclohexanedione
Ozaki, Yutaka,Quan, Zhe-Shan,Watabe, Kyouko,Kim, Sang-Won
, p. 727 - 731 (2007/10/03)
1,4-Cyclohexanedione reacted with 2-oxocarboxylic acids to give 5- hydroxyoxaindan-2-ones including homogentisic lactone in one pot. The obtained aromatic compounds were transformed into indol-5-ols in a few steps. The sequential reactions showed a significance of 1,4-cyclohexanedione as a starting material in aromatic synthesis and an alternative access to the indol-5-ols.
