22464-36-4Relevant academic research and scientific papers
Design, synthesis, and evaluation of novel ethambutol analogues
Yendapally, Raghunandan,Lee, Richard E.
, p. 1607 - 1611 (2008/12/21)
Ethambutol is one of the front-line agents recommended by the World Health Organization for the treatment of tuberculosis. In an effort to develop more potent therapies to treat tuberculosis, novel unsymmetrical ethambutol analogues were successfully synt
Palladium-catalyzed ring opening of isoprene monoxide with nitrogen nucleophiles - Asymmetric synthesis of branched amino sugars
Trost, Barry M.,Jiang, Chunhui,Hammer, Kristin
, p. 3335 - 3345 (2007/10/03)
The Pd-catalyzed regio- and enantioselective ring opening of isoprene monoxide with primary amines as pronucleophiles is developed with good yield and enantioselectivity, constructing a quaternary stereocenter enantioselectively. This methodology was used
Asymmetric synthesis of protected 1,2-amino alcohols using tert-butanesulfinyl aldimines and ketimines
Tang,Volkman,Ellman
, p. 8772 - 8778 (2007/10/03)
tert-Butanesulfinyl aldimines and ketimines bearing an α-benzyloxy or α-silyloxy substituent serve as precursors in the synthesis of protected 1,2-amino alcohols in high yields and diastereoselectivities. General protocols are described for the addition of unbranched alkyl, branched alkyl, and aryl organometallic reagents to N-sulfinyl aldimines 1 and 2 and ketimines 5 and 6. Furthermore, the selective N- or O-deprotection of sulfinamide products 3, 4, 7, and 8 is described, enabling further synthetic transformations of the reaction products.
