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2247127-79-1

2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)-acetamido)pyridazin-3-yl)butyl)-1,3,4-selenadiazol-2-yl)acetamide is a complex organic compound characterized by a long and intricate molecular structure. It features a pyridine ring, a trifluoromethoxy group, an acetamide functional group, and a selenadiazol ring, among other components. 2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)-acetamido)pyridazin-3-yl)butyl)-1,3,4-selenadiazol-2-yl)acetamide is likely to have a diverse range of potential applications, particularly in the pharmaceutical and chemical industries. Further scientific research and experimentation would be necessary to fully understand its specific properties and explore its potential uses.

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  • 2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)-acetamido)pyridazin-3-yl)butyl)-1,3,4-selenadiazol-2-yl)acetamide

    Cas No: 2247127-79-1

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  • 2247127-79-1 Structure

  • Basic information

    1. Product Name: 2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)-acetamido)pyridazin-3-yl)butyl)-1,3,4-selenadiazol-2-yl)acetamide
    2. Synonyms:
    3. CAS NO:2247127-79-1
    4. Molecular Formula:
    5. Molecular Weight: 618.477
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 2247127-79-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)-acetamido)pyridazin-3-yl)butyl)-1,3,4-selenadiazol-2-yl)acetamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)-acetamido)pyridazin-3-yl)butyl)-1,3,4-selenadiazol-2-yl)acetamide(2247127-79-1)
    11. EPA Substance Registry System: 2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)-acetamido)pyridazin-3-yl)butyl)-1,3,4-selenadiazol-2-yl)acetamide(2247127-79-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2247127-79-1(Hazardous Substances Data)

2247127-79-1 Usage

Uses

Used in Pharmaceutical Industry:
2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)-acetamido)pyridazin-3-yl)butyl)-1,3,4-selenadiazol-2-yl)acetamide is used as a potential therapeutic agent for [application reason], given its complex molecular structure and the presence of various functional groups that may interact with biological targets.
Used in Chemical Industry:
In the chemical industry, 2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)-acetamido)pyridazin-3-yl)butyl)-1,3,4-selenadiazol-2-yl)acetamide is used as a key intermediate in the synthesis of [application type], due to its unique structural features that can be exploited in the production of advanced materials or specialty chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 2247127-79-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,2,4,7,1,2 and 7 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2247127-79:
(9*2)+(8*2)+(7*4)+(6*7)+(5*1)+(4*2)+(3*7)+(2*7)+(1*9)=161
161 % 10 = 1
So 2247127-79-1 is a valid CAS Registry Number.

2247127-79-1Downstream Products

2247127-79-1Relevant articles and documents

Novel 1,3,4-Selenadiazole-Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity

Chen, Zhao,Li, Di,Xu, Ning,Fang, Jinzhang,Yu, Yan,Hou, Wei,Ruan, Haoqiang,Zhu, Panpan,Ma, Renchao,Lu, Shiying,Cao, Danhui,Wu, Rui,Ni, Mowei,Zhang, Wei,Su, Weike,Ruan, Benfang Helen

, p. 589 - 603 (2019)

Kidney-type glutaminase [KGA/isoenzyme glutaminase C (GAC)] is becoming an important tumor metabolism target in cancer chemotherapy. Its allosteric inhibitor, CB839, showed early promise in cancer therapeutics but limited efficacy in in vivo cancer models. To improve the in vivo activity, we explored a bioisostere replacement of the sulfur atom in bis-2-(5-phenylacetamido-1,2,4-thiadiazol)ethyl sulfide and CB839 analogues with selenium using a novel synthesis of the selenadiazole moiety from carboxylic acids or nitriles. The resulting selenadiazole compounds showed enhanced KGA inhibition, more potent induction of reactive oxygen species, improved inhibition of cancer cells, and higher cellular and tumor accumulation than the corresponding sulfur-containing molecules. However, both CB839 and its selenium analogues show incomplete inhibition of the tested cancer cells, and a partial reduction in tumor size was observed in both the glutamine-dependent HCT116 and aggressive H22 liver cancer xenograft models. Despite this, tumor tissue damage and prolonged survival were observed in animals treated with the selenium analogue of CB839.

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