22472-33-9Relevant academic research and scientific papers
Discovery of novel phenoxazinone derivatives as DKK1/LRP6 interaction inhibitors: Synthesis, biological evaluation and structure-activity relationships
Thysiadis, Savvas,Mpousis, Spyros,Avramidis, Nicolaos,Katsamakas, Sotirios,Balomenos, Athanasios,Remelli, Rosaria,Efthimiopoulos, Spyros,Sarli, Vasiliki
, p. 1014 - 1022 (2016)
Amino derivatives of NCI8642 were synthesized and evaluated as inhibitors of DKK1/LRP6 interactions. The new inhibitors were able to activate the Wnt signaling pathway as indicated by the increased levels of β-catenin, and decrease the DKK1-induced Tau ph
