224776-14-1 Usage
General Description
Methyl 3-pyrimidin-5-yl-acrylate is a chemical compound with the molecular formula C9H8N2O2. It is an acrylate ester derivative of pyrimidine and is commonly used as a chemical building block in organic synthesis. METHYL 3-PYRIMIDIN-5-YL-ACRYLATE has the potential to be used in the production of pharmaceuticals, agrochemicals, and materials. It can also be utilized in the synthesis of various heterocyclic compounds. Methyl 3-pyrimidin-5-yl-acrylate may also exhibit bioactivity and has been studied for its potential as a drug candidate. Additionally, it can be used as a reagent in chemical research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 224776-14-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,4,7,7 and 6 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 224776-14:
(8*2)+(7*2)+(6*4)+(5*7)+(4*7)+(3*6)+(2*1)+(1*4)=141
141 % 10 = 1
So 224776-14-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H8N2O2/c1-12-8(11)3-2-7-4-9-6-10-5-7/h2-6H,1H3/b3-2+
224776-14-1Relevant articles and documents
PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2
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Page/Page column 27, (2012/06/30)
The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease, and/or diabetic macular edema (I).
A preparative route to methyl 3-(heteroaryl)acrylates using Heck methodology
Kwok, Thomas J.,Virgilio, Joseph A.
, p. 694 - 696 (2012/12/25)
Methyl 3-(heteroaryl)acrylates were prepared using Heck coupling of heteroarene halides with methyl acrylate mediated by Pd(OAc)2/ P(OCH3)3. Reactions were highly efficient (reaction times between 60 and 120 min) and scalable to 100 g of heteroarene halide. The isolated yields are from 76 to 99%.
