224811-44-3Relevant academic research and scientific papers
Pd(II)-Catalyzed Direct ?-C(sp3)-H Arylation between Free β2-Amino Esters and β3-Amino Esters and Aryl Iodides Using a Catalytic Transient Directing Group
Wang, Zhaohui,Fu, Yangjie,Zhang, Qiyu,Liu, Hong,Wang, Jiang
, p. 7683 - 7693 (2020)
Pd(II)-catalyzed direct ?-C(sp3)-H arylation coupling with free β2-amino esters and β3-amino esters using a commercially available catalytic transient directing group has been developed. This approach features high efficiency, broad substrate tolerance, easily accessible starting materials, and mild reaction conditions.
Solid-Phase Synthesis of 3,4,5-Substituted 1,5-Benzodiazepin-2-ones
Lee, Jung,Gauthier, Diane,Rivero, Ralph A.
, p. 3060 - 3065 (2007/10/03)
The preparation of 3,4,5-substituted 8-carboxamido-1,5-benzodiazepin-2-ones using a solid-phase synthetic method is described. 4-Fluoro-3-nitrobenzoic acid is tethered to a solid support via the acid group. Aromatic substitution of the aryl fluoride with either an α- or β-substituted β-amino ester is carried out in the presence of DIEA in DMF. The reduction of the aryl nitro group is accomplished in the presence of SnCl2?H2O. Hydrolysis of the ester is carried out in the presence of a heterogeneous mixture of 1 N NaOH/THF (1:1). The resulting aniline acid is cyclized to form the benzodiazepinone skeleton with DIC and HOBt. Selective alkylation at the N-5 position of the benzodiazepinone is accomplished with alkyl halides in the presence of K2CO3 in acetone. The desired products are cleaved from solid supports and obtained in 46-98% isolated yields.
