224819-05-0Relevant articles and documents
Synthesis and carbonic anhydrase inhibition studies of sulfonamide based indole-1,2,3-triazole chalcone hybrids
Angeli, Andrea,Arifuddin, Mohammed,Purnachander Yadav, P.,Sigalapalli, Dilep Kumar,Singh, Priti,Supuran, Claudiu T.,Swain, Baijayantimala,Thacker, Pavitra S.
, (2020)
Sulfonamide is one of the most promising classes of classical carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. A novel series of indolylchalcones incorporating benzenesulfonamide-1,2,3-triazole (6a-q) has been synthesized by click chemistry reaction and in
Discovery of a novel series of indolylchalcone-benzenesulfonamide hybrids acting as selective carbonic anhydrase II inhibitors
Singh, Priti,Purnachander Yadav, Parvatha,Swain, Baijayantimala,Thacker, Pavitra S.,Angeli, Andrea,Supuran, Claudiu T.,Arifuddin, Mohammed
, (2021/02/03)
The primary sulfonamide group is one of the most efficient zinc binding group (ZBG) for designing carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. In the present study primary sulfonamide linked with indolylchalcone were designed. The newly synthesized molecules (5a-r) were examined against four human (h) CA isoforms (hCA I, hCA II, hCA IX and hCA XIII). These sulfonamides showed good inhibition activity against isoforms hCA I, hCA II and hCA XIII. Compound 5i (2.3 nM), 5m (2.4 nM), 5o (3.6 nM) and 5q (7.0 nM) were more potent than standard drug AAZ (12.1 nM) against isoform hCA II, respectively. Most of the other compounds in the present series inhibited hCA XIII and hCA IX in the range of 50 nM ? 100 nM.
Synthesis and anticancer activity studies of indolylisoxazoline analogues
Chaitanya,Reddy, P.O. Venkataramana,Nikhil, Kumar,Kumar, Anil,Shah, Kavita,Kumar, Dalip
supporting information, p. 2842 - 2845 (2018/08/03)
A new library of thirteen indolylisoxazolines 6a–m has been synthesized by the treatment of indolylchalcones with hydroxylamine hydrochloride. Evaluation of anticancer activity of indolylisoxazolines 6a–m led to the identification of potent compounds 6c–d
Synthesis and biological evaluation of indolyl chalcones as antitumor agents
Kumar, Dalip,Kumar, N. Maruthi,Akamatsu, Kanako,Kusaka, Eriko,Harada, Hiroshi,Ito, Takeo
experimental part, p. 3916 - 3919 (2010/08/20)
A series of indolyl chalcones were synthesized and evaluated in vitro for their anticancer activity against three human cancer cell lines. Compounds 3b-d, 3h, 3j, 3l, 3m, 4g, and 4j showed significant cytotoxicity, particularly, indolyl chalcones 3l and 3
