22488-10-4Relevant academic research and scientific papers
Isolation and structure elucidation of gymnemic acids, antisweet principles of Gymnema sylvestre
Liu,Kiuchi,Tsuda
, p. 1366 - 1375 (2007/10/02)
The structure of gymnemagenin (3β,16β,21β,22α,23,28-hexahydroxy-olean-12-ene), the sapogenin of the antisweet principles of Gymnema sylvestre, was established by X-ray analysis of the 3β,23;21β,22α-di-O-isopropylidene derivative. On the basis of this result, the structure of deacylgymnemic acid was elucidated as the 3-O-β-glucuronide from the carbon-13 nuclear magnetic resonance spectra. Five antisweet principles, gymnemic acid-III, -IV, -V, -VIII, and -IX, were isolated in pure states from the hot water extract of leaves of Gymnema sylvestre. Of these, three (GA-III, -IV, and -V) were known, while two (GA-VIII and-IX) were new compounds. The structures of GA-VIII and -IX were elucidated as 3'-O-β-D-arabino-2-hexulopyranosyl gymnemic acid-III and -IV, respectively.
ESTABLISHMENT OF THE STRUCTURE OF GYMNEMAGENIN BY X-RAY ANALYSIS AND THE STRUCTURE OF DEACYLGYMNEMIC ACID
Tsuda, Yoshisuke,Kiuchi, Fumiyuki,Liu, Hong-Min
, p. 361 - 362 (2007/10/02)
The strucuture of gymnemagenin, the sapogenin of antisweet principle of Gymnema syrvestre, was firmly established as 3β,16β,21β,22α,23,28-hexahydroxy-olean-12-ene by the X-ray analysis of the 3β,23;21β,22α-di-O-isopropylidine derivative.On the basis of this result, the structure of deacylgymnemic acid was elucidated as the 3-O-β-glucuronide by comparison of the 13C-NMR spectra.
