22489-66-3

Usage

Uses

Given the provided materials, there are no specific applications listed for (3aR,4S,6aR,9S,9aR,9bR)-4-hydroxy-9-methyl-3,6-dimethylideneoctahydroazuleno[4,5-b]furan-2,8(3H,4H)-dione. However, based on its classification as a naturally occurring compound with a complex structure, potential uses in the following industries can be hypothesized:
Used in Pharmaceutical Industry:
(3aR,4S,6aR,9S,9aR,9bR)-4-hydroxy-9-methyl-3,6-dimethylideneoctahydroazuleno[4,5-b]furan-2,8(3H,4H)-dione could be used as a pharmaceutical agent for [specific medical condition or treatment] due to its unique chemical structure, which may exhibit biological activity beneficial for [specific medical purpose].
Used in Chemical Research Industry:
In the chemical research industry, (3aR,4S,6aR,9S,9aR,9bR)-4-hydroxy-9-methyl-3,6-dimethylideneoctahydroazuleno[4,5-b]furan-2,8(3H,4H)-dione could serve as a subject for studying the synthesis of complex organic molecules, their properties, and potential reactions, contributing to the advancement of organic chemistry and the discovery of new compounds with practical applications.

Upstream product

• 248584-41-0 N-[4-((3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-9-methyl-6-methylene-2,8-dioxo-dodecahydro-azuleno[4,5-b]furan-3-ylmethylsulfanyl)-phenyl]-acetamide 
• 248584-42-1 (3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-3-(4-methoxy-phenylsulfanylmethyl)-9-methyl-6-methylene-octahydro-azuleno[4,5-b]furan-2,8-dione 
• 248584-38-5 (3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-9-methyl-6-methylene-3-m-tolylsulfanylmethyl-octahydro-azuleno[4,5-b]furan-2,8-dione 
• 248584-40-9 (3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-9-methyl-6-methylene-3-phenylsulfanylmethyl-octahydro-azuleno[4,5-b]furan-2,8-dione 
• 100187-62-0 crepiside D 
• 248584-37-4 (3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-9-methyl-6-methylene-3-p-tolylsulfanylmethyl-octahydro-azuleno[4,5-b]furan-2,8-dione 
• 248584-39-6 (3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-9-methyl-6-methylene-3-o-tolylsulfanylmethyl-octahydro-azuleno[4,5-b]furan-2,8-dione 
• 248584-43-2 (3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-3-(3-methoxy-phenylsulfanylmethyl)-9-methyl-6-methylene-octahydro-azuleno[4,5-b]furan-2,8-dione 
• 248584-44-3 (3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-3-(2-methoxy-phenylsulfanylmethyl)-9-methyl-6-methylene-octahydro-azuleno[4,5-b]furan-2,8-dione 
• 84305-03-3 grosheiminol 

Downstream Products

• 125403-32-9 11-H-13-Se-phenyl grosheimin 
• 125403-31-8 11-H, 13-ethoxy grosheimin 
• 518034-55-4 cynarascolide 
• 84305-03-3 grosheiminol 
• 248584-42-1 (3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-3-(4-methoxy-phenylsulfanylmethyl)-9-methyl-6-methylene-octahydro-azuleno[4,5-b]furan-2,8-dione 
• 248584-38-5 (3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-9-methyl-6-methylene-3-m-tolylsulfanylmethyl-octahydro-azuleno[4,5-b]furan-2,8-dione 
• 248584-43-2 (3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-3-(3-methoxy-phenylsulfanylmethyl)-9-methyl-6-methylene-octahydro-azuleno[4,5-b]furan-2,8-dione 
• 248584-44-3 (3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-3-(2-methoxy-phenylsulfanylmethyl)-9-methyl-6-methylene-octahydro-azuleno[4,5-b]furan-2,8-dione 
• 248584-40-9 (3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-9-methyl-6-methylene-3-phenylsulfanylmethyl-octahydro-azuleno[4,5-b]furan-2,8-dione 
• 248584-37-4 (3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-9-methyl-6-methylene-3-p-tolylsulfanylmethyl-octahydro-azuleno[4,5-b]furan-2,8-dione 
• 248584-39-6 (3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-9-methyl-6-methylene-3-o-tolylsulfanylmethyl-octahydro-azuleno[4,5-b]furan-2,8-dione 
• 248584-41-0 N-[4-((3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-9-methyl-6-methylene-2,8-dioxo-dodecahydro-azuleno[4,5-b]furan-3-ylmethylsulfanyl)-phenyl]-acetamide 

Relevant academic research and scientific papers

Phenylthio-derivatives of α-methylene-γ-lactones as pro-drugs of cytotoxic agents

A series of substituted phenylthio-derivatives of grosheimin (1), a natural cytotoxic guaianolide, were investigated with the aim of providing insight into their mechanism of action as cytotoxic agents against KB cell lines. Hydrolysis data, kinetics, in the presence and in the absence of H2O2, and the valuation of lipophilicity were correlated with cytotoxicity values and with Hammett-σ-values of substituents (R) at the thiophenol ring. These compounds behave as 'pro-drugs' which release the cytotoxic agent grosheimin by sulphur-oxidation promoted by H2O2 and subsequent retro- elimination which depends on the nature and position of the R substituent.

Studies on Sesquiterpene Glycosides from Crepis japonica BENTH.

Nine new guaianolide-type glycosides, crepisides A(II), B(III), C(IV), D(V), E(VI), F(VII), G(VIII), H(IX) anf I(X), have been isolated from Crepis japonica BENTH., together with a known glycoside, glucozaluzanin C(I).The structures of II-X were established on the basis of chemical and spectral data.Keywords - Crepis japonica; Compositae; sesquiterpene glycoside; guaianolide; crepiside

SESQUITERPENIC LACTONES FROM Grossheimia macrocephala. STRUCTURE OF GROSHEIMINOL

From the leaves of Grossheimia macrocephala (MUSS.-PUSCHK.) D.SOSN. et TAKHT. cynaropicrin (II), isolipidiol (III) and the so far undescribed lactone grosheiminol (IV) were isolated in addition to grosheimin (I), detected in this species earlier.For grosheiminol the structure IV was derived, including relative and absolute configuration, on the basis of chemical correlation.