22489-94-7

Upstream product

• 101-41-7 benzeneacetic acid methyl ester 
• 22489-95-8 2-phenyl-2-prop-2-ynylpent-4-ynoic acid methyl ester 

Relevant academic research and scientific papers

Enantioselective, desymmetrizing bromolactonization of alkynes

Asymmetric bromolactonizations of alkynes are possible using a desymmetrization approach. The commercially available catalyst (DHQD) 2PHAL promotes these cyclizations in combination with cheap NBS as a bromine source to give bromoenol lactones in high yield and with high enantioselectivity. The bromoenol lactone products, containing a tetrasubstituted alkene and a quaternary stereocenter, are valuable building blocks for synthetic chemistry.