224947-58-4Relevant academic research and scientific papers
Synthesis of trans-syn-trans fused bis-pyrans via endo-selective cyclizations of cyclic sulfates
McDonald, Frank E.,Vadapally, Prahlad
, p. 2235 - 2238 (2007/10/03)
Acid-catalyzed cyclization of hydroxy-cyclic sulfates occurs with endo- regioselectivity affording bispyran products from substrates in which the nucleophilic hydroxyl and electrophilic cyclic sulfate groups are 1,2-trans- substituted on a cyclic pyran template. This methodology is demonstrated in an enantioselective synthesis of the trans-syn-trans fused AB cyclic ether rings of the brevetoxin natural products.
