224948-24-7

Basic information

• Product Name: 2-(2-fluorobenzylidene)-3,4-dihydro-1(2H)-naphthalenone
• Synonyms: 2-(2-fluorobenzylidene)-3,4-dihydro-1(2H)-naphthalenone
• CAS NO: 224948-24-7
• Molecular Formula: C17H13FO
• Molecular Weight: 252.2829232
• Mol File: 224948-24-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-fluorobenzylidene)-3,4-dihydro-1(2H)-naphthalenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-fluorobenzylidene)-3,4-dihydro-1(2H)-naphthalenone(224948-24-7)
• EPA Substance Registry System: 2-(2-fluorobenzylidene)-3,4-dihydro-1(2H)-naphthalenone(224948-24-7)

Safety Data

• Hazardous Substances Data: 224948-24-7(Hazardous Substances Data)

Upstream product

• 446-52-6 2-Fluorobenzaldehyde 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 

Downstream Products

• 685130-51-2 C₁₈H₁₅FN₂S 

Relevant articles and documents

Novel 1-tetralone chalcone and composition for preventing or treating inflammatory disease comprising the same as active ingredient

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Basic Anion-Exchange Resin-Catalyzed Aldol Condensation of Aromatic Ketones with Aldehydes in Continuous Flow

A general method for the aldol condensation of aromatic ketones with aldehydes was developed under continuous-flow conditions using a commercially available, strongly basic anion-exchange resin (A26) as catalyst. This procedure, in addition to exhibiting a wide substrate scope, promoted carbon-carbon bond formation under mild conditions using a quasi-stoichiometric ratio of starting reagents with good to excellent yields, thereby forming a limited amount of waste and allowing the process to be applied to sequential-flow systems. A proof of concept was developed in the first fully heterogeneously catalyzed two-step flow synthesis of donepezil, which is a blockbuster commercial anti-Alzheimer's drug.

E-2-benzylidenebenzocycloalkanones. Stereostructure and NMR spectroscopic investigation

Series of E-2-benzylideneindanones (a), -tetralones (b) and - benzosuberones (c) with OCH3 (2-4), NO2 (5-7) and F (8-10) substitutions (ortho, meta and para) on their benzylidene moiety were synthesized by aldol condensation of the a