225-55-8

Basic information

• Product Name: 6H-chromeno[4,3-b]quinoline
• Synonyms: 6H-[1]Benzopyrano[4,3-b]quinoline
• CAS NO: 225-55-8
• Molecular Formula: C₁₆H₁₁NO
• Molecular Weight: 233.2646
• Mol File: 225-55-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 121.5 °C
• Boiling Point: 447.8°C at 760 mmHg
• Flash Point: 160.8°C
• Density: 1.264g/cm³
• Vapor Pressure: 8.66E-08mmHg at 25°C
• Refractive Index: 1.7
• PKA: 4.14±0.20(Predicted)
• CAS DataBase Reference: 6H-chromeno[4,3-b]quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6H-chromeno[4,3-b]quinoline(225-55-8)
• EPA Substance Registry System: 6H-chromeno[4,3-b]quinoline(225-55-8)

Safety Data

• Hazardous Substances Data: 225-55-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 24, p. 2379, 1983 DOI: 10.1016/S0040-4039(00)81930-9

Upstream product

• 90-02-8 salicylaldehyde 
• 446-52-6 2-Fluorobenzaldehyde 
• 105271-79-2 C₁₆H₁₂ClNO 
• 333785-07-2 N-(2-(prop-2-ynyloxy)benzylidene)benzenamine 
• 29978-83-4 o-propargyloxybenzaldehyde 
• 62-53-3 aniline 
• 14063-82-2 4-chloro-2H-chromene-3-carboxaldehyde 
• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 529-23-7 o-aminobenzaldehyde 
• 87591-57-9 [1-(4-Chloro-2H-chromen-3-yl)-meth-(E)-ylidene]-phenyl-amine 
• 65038-75-7 Phenyl-{3-[(E)-phenyliminomethyl]-2H-chromen-4-yl}-amine; hydrochloride 
• 66362-36-5 propargyloxy-2 salicylanilide 
• 65038-75-7 phenyl-[3-(phenylimino-methyl)-2H-chromen-4-yl]-amine; hydrochloride 

Relevant articles and documents

Methode simple de synthese de la 6H- benzopyranno quinoleine.

A facile synthesis of 6H- benzopyranno quinoline is achieved from propargyloxysalicylanilide (yield 72 percent).Reaction mechanism postulates the attack of triple bond by a nitrilium salt.

Copper-catalyzed formal [3 + 3] annulations of arylketoximes and o-fluorobenzaldehydes: An entry to quinoline compounds

A copper-based catalytic system has been developed to enable efficient cyclization of ketoxime acetates with ofluorobenzaldehydes. This protocol offers an efficient method for the synthesis of substituted quinoline derivatives with a broad range of compatible functionalities. The present system also provides a rapid access to synthetically and pharmaceutically useful quinoline-fused polycycles such as benzo[c]acridines.

Copper-Catalyzed Aza-Diels-Alder Reaction and Halogenation: An Approach to Synthesize 7-Halogenated Chromenoquinolines

A new halogenation method to construct halogen-substituted quinoline moieties is described. The Cu-catalyzed intramolecular aza-Diels-Alder reaction and halogenation reaction proceeded smoothly under mild conditions to produce the corresponding 7-chloro-6H-chromeno[4,3-b]quinolines and 7-chloro-6H-thiochromeno[4,3-b]quinolines in satisfactory yields.