225112-60-7Relevant academic research and scientific papers
Preparation and in-vitro evaluation of 4-benzylsulfanylpyridine-2- carbohydrazides as potential antituberculosis agents
Herzigova, Petra,Klimesova, Vera,Palat, Karel,Kaustova, Jarmila,Dahse, Hans-Martin,Moellmann, Ute
scheme or table, p. 394 - 404 (2009/11/30)
A set of 4-benzylsulfanylpyridine-2-carbohydrazides was synthesized and evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, non-tuberculous mycobacteria, and multidrug-resistant M. tuberculosis. The activities expressed as the minimum inhibitory concentration (MIC) fall into a range of 2 to 125 μmol/L, most often 4 to 32 μmol/L. The results revealed that the substituents on the benzyl moiety do not influence the antimycobacterial efficacy. The substances exhibited similar activities against sensitive and resistant strains of M. tuberculosis. Furthermore, compounds show low antiproliferative effect and cytotoxicity.
Synthesis and antimicrobial activity of new 4-(benzylsulfanyl)pyridine derivatives
Klimesova, Vera,Svoboda, Martin,Waisser, Karel,Pour, Milan,Kaustova, Jarmila
, p. 417 - 434 (2007/10/03)
A series of 4-(benzylsulfanyl)pyridine-2-carbonitriles 2 and 4-(benzylsulfanyl)pyridine-2-carbothioamides 3 was synthesized and their antimycobacterial and antifungal activities were tested. The prepared compounds exhibit significant activity both against M. tuberculosis and nontuberculous mycobacteria. The most active compounds show the MICs of 4 μmol/1. The antifungal activities of 2 are very weak, compounds 3 are inactive against all the tested fungi.
