22515-39-5Relevant articles and documents
An efficient method for the synthesis of 2-pyridones: Via C-H bond functionalization
Zhou, Shuguang,Liu, Duan-Yang,Wang, Suo,Tian, Jie-Sheng,Loh, Teck-Peng
supporting information, p. 15020 - 15023 (2020/12/23)
A simple and practical method to access N-substituted 2-pyridones via a formal [3+3] annulation of enaminones with acrylates based on RhIII-catalyzed C-H functionalization was developed. Control and deuterated experiments led to a plausible mechanism involving C-H bond cross-coupling and aminolysis cyclization. This strategy provides a short synthesis of structural motifs of N-substituted 2-pyridones.
Ruthenium-catalyzed asymmetric hydrogenation of β-keto- enamines: An efficient approach to chiral γ-amino alcohols
Geng, Huiling,Zhang, Xiaowei,Chang, Mingxin,Zhou, Le,Wu, Wenjun,Zhang, Xumu
supporting information; experimental part, p. 3039 - 3043 (2012/01/02)
A highly efficient and enantioselective hydrogenation of unprotected β-ketoenamines catalyzed with ruthenium(II) dichloro{(S)-(-)-2,2′- bis[di(3,5-xylyl)phosphino]-1,1′-binaphthyl}[(2S)-(+)-1, 1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine] {Ru[(S)-xylbinap][(S)-daipen] Cl2} has been successfully developed. This methodology provides a straightforward access to free γ-secondary amino alcohols, which are key building blocks for a variety of pharmaceuticals and natural products, with high yields (>99%) and excellent enantioselectivities (up to 99% ee) in all cases. Copyright
