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3-(4-hydroxy-3-methylphenyl)propanenitrile, also known as 3-(4-hydroxy-3-methylphenyl)acrylonitrile, is an organic compound with the chemical formula C10H9NO. It is a derivative of acrylonitrile, featuring a phenyl ring with a hydroxyl group at the para position and a methyl group at the ortho position. 3-(4-hydroxy-3-methylphenyl)propanenitrile is characterized by its nitrile functional group, which is a triple-bonded nitrogen atom attached to a carbon atom. It is a colorless to pale yellow liquid with a molecular weight of 159.19 g/mol. Due to its reactive nature, it is often used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. The compound is sensitive to light and heat, and it is typically stored under controlled conditions to prevent degradation.

22516-99-0

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22516-99-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 22516-99-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,5,1 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 22516-99:
(7*2)+(6*2)+(5*5)+(4*1)+(3*6)+(2*9)+(1*9)=100
100 % 10 = 0
So 22516-99-0 is a valid CAS Registry Number.

22516-99-0Relevant academic research and scientific papers

Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction

Yin, Hang,Lee, Gui-In,Hyung, Soon Park,Payne, Gregory A.,Rodriguez, Johanna M.,Sebti, Said M.,Hamilton, Andrew D.

, p. 2704 - 2707 (2007/10/03)

(Chemical Equation Presented) HDM2 regulates p53 by binding to its transactivation domain and promoting its ubiquitin-dependent degradation. Crystallographic analysis of the HDM2/p53 complex revealed that three hydrophobic residues (F19, W23, L26) along one face of the p53 helical peptide are essential for binding (see picture). Terphenyl-based antagonists mimic the α-helical region of p53 and disrupt HDM2/p53 complexation.

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