225217-66-3Relevant academic research and scientific papers
Cyclization of tautomeric 1,5-dinitrile systems with hydrogen halides: A definitive mechanistic rationalization?
Teixido, Jordi,Borrell, Jose I.,Serra, Blanca,Matallana, Josep Lluis,Colominas, Carles,Carrion, Francisco,Pascual, Rosalia,Falco, Josep Lluis,Batllori, Xavier
, p. 739 - 756 (2007/10/03)
A new mechanistic rationalization for the cyclization with hydrogen halides of tautomeric 1,5-dinitriles of general structures (10) (Z = N), (14) (Z = C-CN), (16) (Z = N), and (18) (Z = C-CN) is proposed (Scheme 5). In such rationalization, three factors
A SYNTHESIS OF 1,2,3,4-TETRAHYDRO-1,6-NAPHTHYRIDINES
Victory, Pedro J.,Teixido, Jordi,Borrell, Jose I.
, p. 1905 - 1916 (2007/10/02)
8-Cyano-3,4-dihydro-1,6-naphthyridin-2(1H)-ones were obtained by nucleophilic substitution of the methoxyl group of 5-cyano-3,4-dihydro-6-methoxy-2(1H)-pyridones (5a-d) by malononitrile or cyanoacetamide followed by cyclization in acidic or basic medium.
