225237-20-7Relevant academic research and scientific papers
1,3,5-triaza-7-phosphaadamantane (PTA): A practical and versatile nucleophilic phosphine organocatalyst
Tang, Xiaofang,Zhang, Bo,He, Zhengrong,Gao, Ruili,He, Zhengjie
, p. 2007 - 2017 (2007)
In this paper, the air-stable and readily available 1,3,5-triaza-7- phosphaadmantane (PTA) is reported as a practical and versatile nucleophilic phosphine organocatalyst. Under the mediation of 15-30 mol% of PTA, various electrophiles like aldehydes and i
Simple and one-pot synthesis of tri and tetracyclic frameworks containing [1,8]naphthyridin-2-one moiety from the Baylis-Hillman adducts
Basavaiah, Deevi,Reddy, Kanumuri Ramesh
, p. 1215 - 1219 (2010)
A facile synthesis of tri and tetracyclic frameworks containing [1,8]naphthyridin-2-one skeleton from the Baylis-Hillman alcohols via the Johnson-Claisen rearrangement, followed by the treatment with Fe/AcOH in simple one-pot multi-step process is describ
Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis
Cocco, Mattia,Garella, Davide,Di Stilo, Antonella,Borretto, Emily,Stevanato, Livio,Giorgis, Marta,Marini, Elisabetta,Fantozzi, Roberto,Miglio, Gianluca,Bertinaria, Massimo
, p. 10366 - 10382 (2015/02/19)
Pyroptosis is a caspase-1-dependent pro-inflammatory form of programmed cell death implicated in the pathogenesis of autoinflammatory diseases as well as in disorders characterized by excessive cell death and inflammation. Activation of NLRP3 inflammasome
Electrochemical and computational studies, in protic medium, of Morita-Baylis-Hillman adducts and correlation with leishmanicidal activity
De Paiva, Yen G.,Pinho Júnior, Waldomiro,De Souza, Antonio A.,Costa, Cícero O.,Silva, Fábio P.L.,Lima-Junior, Cláudio G.,Vasconcellos, Mario L.A.A.,Goulart, Marília O.F.
, p. 557 - 563 (2015/02/02)
Enzymatic bioreduction of nitro groups plays an important role on the activity of biologically active nitroaromatic compounds. Electrochemical methods are useful tools to simulate in vivo metabolic processes. This work presents electrochemical studies, in
Micellar promiscuity: An expeditious approach to Morita-Baylis-Hillman reaction
Shairgojray, Bashir Ahmad,Dar, Aijaz Ahmad,Bhat, Bilal Ahmad
, p. 2391 - 2394 (2013/06/27)
An accelerated and efficient method for Morita-Baylis-Hillman (MBH) reaction in aqueous cationic micellar solution under ambient conditions has been developed. The present method holds promise for future use of cyclic and acylic MBH-adducts of general uti
Antimitotic activity on sea urchin embryonic cells of seven antiparasitic morita-baylis-hillman adducts: A potential new class of anticancer drugs
Leite, Jocelmo C. A.,Marques-Santos, Luis F.,Claudio Jr., G. L.,Silva, Fabio P. L.,Sousa, Suervy C. O.,Vasconcellos, Mario L. A. A.
, p. 1003 - 1011,9 (2012/12/12)
In the present work we described improvements in the 1-7 antiparasitic Morita-Baylis-Hillman Adducts synthesis and their antimitotic activity on sea urchin embryonic cells. The 2-[Hydroxy(2-nitrophenyl)methyl]acrylonitrile (1) and 2-[Hydroxy(4-bromophenyl
Highly efficient synthesis of novel Morita-Baylis-Hillman adducts from activated ketones using a DABCO-based hydroxy ionic liquid (HIL) as a recyclable catalyst-solvent
Khalafi-Nezhad, Ali,Mohammadi, Somayeh
experimental part, p. 1725 - 1735 (2012/07/01)
A highly efficient non-imidazolium DABCO-based ionic liquid has been prepared for the synthesis of biologically active Morita-Baylis-Hillman adducts from activated ketones. The results show that the ionic liquid is very efficient in the Morita-Baylis-Hill
Correlation between electrochemical and theoretical studies on the leishmanicidal activity of twelve Morita-Baylis-Hillman adducts
De Paiva, Yen G.,De Souza, Anto?nio A.,Lima-Junior, Claudio G.,Silva, Fa?bio P. L.,Filho, Edilson B. A.,De Vasconcelos, Camila C.,De Abreu, Fabiane C.,Goulart, Mari?lia O. F.,Vasconcellos, Ma?rio L. A. A.
scheme or table, p. 894 - 904 (2012/06/18)
Enzymatic bioreduction of nitro groups plays an important role on the activity of biologically active nitroaromatic compounds. Electrochemical methods are useful tools to simulate in vivo metabolic processes. This work presents electrochemical studies in
Microwave irradiation or low temperature improved synthesis of antiparasitic morita-baylis-hillman adducts
Claudio Jr.,Silva, Fabio P.L.,De Oliveira, Ramon G.,Subrinho, Fernanda L.,De Andrade, Natalia G.,Vasconcellos, Mario L.A.A.
scheme or table, p. 2220 - 2224 (2012/02/03)
It is reported the synthesis of 24 Morita-Baylis-Hillman adducts (3a-3l/6a-6l) using microwave irradiation at 80 °C or conventional protocol at 0 °C to promote the reactions between aromatic aldehydes and methyl acrylate or acrylonitrile (81-99%). It is shown that the reaction of 2-hydroxy(4-bromophenyl)methyl acrylate formation is reversible at 120 °C.
Efficient synthesis of 16 aromatic Morita-Baylis-Hillman adducts: Biological evaluation on Leishmania amazonensis and Leishmania chagasi
Junior, Claudio G.L.,De Assis, Priscila A.C.,Silva, Fabio P.L.,Sousa, Suervy C.O.,De Andrade, Natalia G.,Barbosa, Ticiano P.,Neris, Patricia L.N.,Segundo, Luiz V.G.,Anjos, Italo C.,Carvalho, Gabriel A.U.,Rocha, Gerd B.,Oliveira, Marcia R.,Vasconcellos, Mario L.A.A.
experimental part, p. 279 - 284 (2011/02/22)
Sixteen aromatic Morita-Baylis-Hillman adducts (MBHA) 1-16 were efficiently synthesized in a one step Morita-Baylis-Hillman reaction (MBHR) involving commercial aldehydes with methyl acrylate or acrylonitrile (81-100% yields) without the formation of side
