22528-79-6

Basic information

• Product Name: 7-Nitro-4-chromanone
• Synonyms: 7-Nitro-4-chromanone;2,3-Dihydro-7-nitro-4H-1-benzopyran-4-one;7-NitrochroMan-4-one
• CAS NO: 22528-79-6
• Molecular Formula: C9H7NO4
• Molecular Weight: 193.15618
• Mol File: 22528-79-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 378.744 °C at 760 mmHg
• Flash Point: 197.658 °C
• Appearance: /
• Density: 1.424 g/cm³
• Vapor Pressure: 6.15E-06mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 7-Nitro-4-chromanone(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Nitro-4-chromanone(22528-79-6)
• EPA Substance Registry System: 7-Nitro-4-chromanone(22528-79-6)

Safety Data

• Hazardous Substances Data: 22528-79-6(Hazardous Substances Data)

Usage

Chemical Properties

light yellow liquid

InChI:InChI=1/C9H7NO4/c11-8-3-4-14-9-5-6(10(12)13)1-2-7(8)9/h1-2,5H,3-4H2

Upstream product

• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 19157-85-8 3-<3-Nitro-phenoxy>-propionitril 
• 554-84-7 meta-nitrophenol 

Downstream Products

• 103440-75-1 7-aminochroman-4-one 

Relevant articles and documents

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

An efficient synthesis of 4-chromanones

A two step efficient and practical synthesis of a variety of 4-chromanones is described. Phenols undergo a Michael addition to acrylonitriles in the presence of catalytic amounts of potassium carbonate and tert-butanol to generate the corresponding 3-aryloxypropanenitriles in 50-93% yields. Treatment of the resulting aryloxypropionitriles with 1.5 equiv of TfOH and 5 equiv of TFA, followed by an aqueous work up afforded 4-chromanones in moderate to excellent yields.