22544-70-3

Basic information

• Product Name: 4H-Imidazol-4-one, 1,5-dihydro-2-(methylthio)-5,5-diphenyl-
• CAS NO: 22544-70-3
• Molecular Formula: C16H14N2OS
• Molecular Weight: 282.366
• Mol File: 22544-70-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4H-Imidazol-4-one, 1,5-dihydro-2-(methylthio)-5,5-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Imidazol-4-one, 1,5-dihydro-2-(methylthio)-5,5-diphenyl-(22544-70-3)
• EPA Substance Registry System: 4H-Imidazol-4-one, 1,5-dihydro-2-(methylthio)-5,5-diphenyl-(22544-70-3)

Safety Data

• Hazardous Substances Data: 22544-70-3(Hazardous Substances Data)

Upstream product

• 21083-47-6 5,5-diphenyl-2-thioxoimidazolidin-4-one 
• 74-88-4 methyl iodide 

Downstream Products

• 16459-73-7 2-Dimethylamino-4-oxo-5-diphenylimidazolin 
• 102157-53-9 3-(2-dimethylamino-ethyl)-2-methylsulfanyl-5,5-diphenyl-3,5-dihydro-imidazol-4-one 
• 26975-77-9 2-methylamino-5,5-diphenyl-1,5-dihydro-imidazol-4-one 
• 78451-64-6 2-benzylamino-5,5-diphenylimidazolin-4-one 
• 22544-72-5 3-methyl-2-methylsulfanyl-5,5-diphenyl-3,5-dihydro-imidazol-4-one 
• 2032-13-5 Thiophenytoin 
• 57-41-0 phenythoin 
• 55251-18-8 3-benzyl-1-methyl-5,5-diphenyl-imidazolidine-2,4-dione 
• 34657-67-5 3-benzyl-5,5-diphenyl-imidazolidine-2,4-dione 
• 70975-69-8 2-(2-hydroxy-ethylamino)-5,5-diphenyl-1,5-dihydro-imidazol-4-one 
• 16116-39-5 1,4-S-Dimethyl-5,5-diphenyl-dithiohydantoin 
• 7000-52-4 1-methyl-4-methylsulfanyl-5,5-diphenyl-1,5-dihydro-imidazol-2-one 
• 2032-17-9 2,5-bis-methylsulfanyl-4,4-diphenyl-4H-imidazole 
• 3718-53-4 4-methylsulfanyl-5,5-diphenyl-1,5-dihydro-imidazole-2-thione 

Relevant articles and documents

-

-

Synthesis and Anticonvulsant Activity of 2-Iminohydantoins

Iminohydantoins selectively substituted at position C-5 and their 1-carbobenzoxy derivatives have been synthesized, and their anticonvulsant activity was evaluated in mice.In general, the more lipophilic 1-carbobenzoxy iminohydantoins were more potent than the unsubstituted counterparts.Evaluation of the individual enantiomers of the chiral iminohydantoins showed that the anticonvulsant activity resided primarily in the S isomers.In this study, (S)-(+)-1-carbobenzoxy-5-isobutyl-2-iminohydantoin (9a) was the most active member.This compound was not nearly as active as phenythoin against electrically induced convulsions, but was also active against pentylenetetrazole-induced seizures, suggesting a broader clinical potential.The closest analogue of phenytoin, viz., 5,5-diphenyl-2-iminohydantoin (1), failed to show any significant activity.Methylation on N-3 or the imino nitrogen of 1 also did not provide a compound with substantial activity. 2-Thiophenytoin was not active against electoshock seizures and showed only a weak activity against pentylenetetrazole.This study suggested that the structure-activity relationship of 2-iminohydantoins was quite different from that of 2-hydantoins.