22551-45-7Relevant articles and documents
Synthesis of cytotoxic cembranolide analogues via acid-induced opening of oxiranes
Rodríguez, Abimael D.,Pi?a, Ivette C.,Acosta, Ana L.,Barnes, Charles L.
, p. 93 - 107 (2007/10/03)
A large series of analogues of Eunicea cembranolides 1-3 were synthesized with the purpose of evaluating their cytotoxicity against 60 human cancer cell-lines. Most of the analogues were as active as the lead compounds and a few displayed increased cytotoxicity. Their syntheses were based on the specific reactivity and stereochemistry of the epoxide substructure and involved highly regio- and diastereoselective acid-induced chemical transformations.
The structure of euniolide, a new cembranoid diterpene from the caribbean gorgonians eunicea succinea and eunicea mammosa
Morales, Jose J.,Espina, Jose R.,Rodriguez, Abimael D.
, p. 5889 - 5894 (2007/10/02)
Three simple γ-lactonic cembranolides were isolated from the gorgonian Eunicea succinea collected near Palomino Key, Puerto Rico on July, 1989. The structure of two were determined from spectral data and chemical correlation experiments to be those of known 12,13-bisepleupalmerin (1) and eunicin (3). The structure of the third metabolite was deduced from spectroscopic data and from chemical degradation experiments to be that of eunlolide (2), a previously undescribed γ-lactonic cembranolide. Extraction of a fresh specimen of Eunicea mammosa collected near Desecheo island Puerto Rico on March, 1989 also afforded sunlolide in addition to known cembranoid diterpene eupalmerin acetate (4).
