225517-65-7

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 177966-66-4 (R)-β-tyrosine methyl ester 
• 84184-51-0 (E)-methyl 3-(4-(benzyloxy)phenyl)acrylate 
• 122747-96-0 (R)-3-(4-Benzyloxy-phenyl)-3-tert-butoxycarbonylamino-propionic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 122747-94-8 3-(4-Benzyloxy-phenyl)-3-tert-butoxycarbonylamino-propionic acid methyl ester 
• 618110-19-3 3-(4-Benzyloxy-phenyl)-3-tert-butoxycarbonylamino-propionic acid 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 225517-50-0 (R)-3-(4-Benzyloxy-phenyl)-3-[benzyl-((S)-1-phenyl-ethyl)-amino]-propionic acid methyl ester 
• 6373-46-2 p-benzyloxyaniline 
• 122871-98-1 (R)-3-(4-Benzyloxy-phenyl)-3-tert-butoxycarbonylamino-propionic acid methyl ester 

Downstream Products

• 122747-93-7 (R)-3-{(R)-3-(2-Bromo-1H-indol-3-yl)-2-[((S)-2-tert-butoxycarbonylamino-propionyl)-methyl-amino]-propionylamino}-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 225517-66-8 N-tert-butoxycarbonyl-3(R)-amino-3-(4-trifluoromethylsulfonyloxyphenyl)propionic acid, methyl ester 
• 122748-00-9 (R)-3-(4-Benzyloxycarbonyloxy-phenyl)-3-{(R)-3-(2-bromo-1H-indol-3-yl)-2-[((S)-2-tert-butoxycarbonylamino-propionyl)-methyl-amino]-propionylamino}-propionic acid methyl ester 
• 122747-99-3 (R)-3-(4-Benzyloxycarbonyloxy-phenyl)-3-[(R)-3-(2-bromo-1H-indol-3-yl)-2-(tert-butoxycarbonyl-methyl-amino)-propionylamino]-propionic acid methyl ester 
• 474295-90-4 [1-(4-dimethylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-methyl-carbamic acid tert-butyl ester 
• 444646-40-6 t-butyl (R)-[1-[(4-dimethylcarbamoyloxy)phenyl]-3-(4-nitrophenoxy)propyl]carbamate 
• 474296-06-5 t-butyl (R)-[1-[(4-dimethylcarbamoyloxy)phenyl]-3-hydroxypropyl] carbamate 

Relevant academic research and scientific papers

BENZYLAMINE ANALOGUE

A compound of the formula (I): [wherein R1 represents a C1-C6 alkyl group etc., R2 and R3 are the same or different and represent a hydrogen atom etc., Ra represents a C1-C6 alkyl group etc., Arom represents an aryl group etc., A represents a C1-C6 alkylene group, E represents a single bond, an oxygen atom, a sulfur atom etc., X1 and X2 are the same or different and represent an oxygen atom or a sulfur atom] or a pharmacologically acceptable salt or ester thereof.

Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists.

A series of substituted N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl- and (L)-azetidyl-beta-biaryl beta-alanine derivatives was prepared as selective and potent VLA-4 antagonists. The 2,6-dioxygenated biaryl substitution pattern is important for optimizing potency. Oral bioavailability was variable and may be a result of binding to circulating plasma proteins.

Design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter targeting potential agents for Alzheimer's disease.

Highly efficient acetylcholinesterase (AChE) and serotonin transporter (SERT) dual inhibitors, (S)-4 and (R)-13 were designed and synthesized on the basis of the hypothetical model of AChE active site. Both compounds showed potent inhibitory activities against AChE and SERT. [structure: see text]

A PRACTICAL SYNTHESIS OF THE PEPTIDE PART OF JASPAMIDE (JASPAKINOLIDE), A CYCLODEPSIPEPTIDE FROM A MARINE SPONGE

(S)-Alanyl-(R)-2-bromoabryl-(R)-β-tyrosine found in jaspamide(1) was conveniently synthesized as its protected derivative 2 in good yield.