225517-81-7 Usage
Uses
Used in Pharmaceutical Industry:
(S)-4-N-CBZ-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER is used as a precursor or intermediate for the synthesis of various pharmaceutical drugs, particularly those aimed at treating central nervous system disorders and related conditions. Its role in drug development is crucial due to its ability to be incorporated into the molecular structures of potential therapeutic agents.
It is important to handle and store (S)-4-N-CBZ-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER with care, as it can be hazardous if not managed properly, ensuring safety in the pharmaceutical development process.
Check Digit Verification of cas no
The CAS Registry Mumber 225517-81-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,5,5,1 and 7 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 225517-81:
(8*2)+(7*2)+(6*5)+(5*5)+(4*1)+(3*7)+(2*8)+(1*1)=127
127 % 10 = 7
So 225517-81-7 is a valid CAS Registry Number.
InChI:InChI=1/C14H18N2O4/c1-19-13(17)12-9-16(8-7-15-12)14(18)20-10-11-5-3-2-4-6-11/h2-6,12,15H,7-10H2,1H3/t12-/m0/s1
225517-81-7Relevant academic research and scientific papers
KINETIC RESOLUTION OF CHIRAL AMINES
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Page/Page column 69; 70; 71; 78; 79; 80, (2013/03/26)
The present invention refers to a method for the kinetic resolution of a chiral primary or secondary amine by treating the amine with a chiral, hydroxamic acid derived reagent of the formula (I). These chiral reagents are particularly useful for the kinetic resolution of cyclic amines and may be generated in situ in the presence of an N-heterocyclic carbene, thus allowing for a catalytic reaction.
Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocycles
Hsieh, Sheng-Ying,Binanzer, Michael,Kreituss, Imants,Bode, Jeffrey W.
supporting information, p. 8892 - 8894 (2012/11/07)
The scope, reactivity, and selectivity of the chiral hydroxamic acid-catalyzed kinetic resolution of chiral amines are improved by a new catalyst structure and a more environmentally friendly reaction protocol. In addition to increasing selectivity across all substrates, these conditions make possible the resolution of N-heterocycles containing lactams or other basic functional groups that can inhibit the catalyst.
