22563-88-8

Basic information

• Product Name: 2-{[(E)-(2-chlorophenyl)methylidene]amino}-2-methylpropan-1-ol
• CAS NO: 22563-88-8
• Molecular Formula: C₁₁H₁₄ClNO
• Molecular Weight: 211.688
• Mol File: 22563-88-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 318.2°C at 760 mmHg
• Flash Point: 146.3°C
• Density: 1.07g/cm³
• Vapor Pressure: 0.000153mmHg at 25°C
• Refractive Index: 1.517
• CAS DataBase Reference: 2-{[(E)-(2-chlorophenyl)methylidene]amino}-2-methylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[(E)-(2-chlorophenyl)methylidene]amino}-2-methylpropan-1-ol(22563-88-8)
• EPA Substance Registry System: 2-{[(E)-(2-chlorophenyl)methylidene]amino}-2-methylpropan-1-ol(22563-88-8)

Safety Data

• Hazardous Substances Data: 22563-88-8(Hazardous Substances Data)

Usage

Classification

Amino alcohol

Molecular weight

211.69 g/mol

Functional groups

Chlorophenyl group, methylidene amino group, methylpropanol group

Uses

Chiral auxiliary in asymmetric synthesis, development of new pharmaceutical compounds

Applications

Research and pharmaceutical settings

Value

Valuable tool for synthetic chemists and medicinal chemists

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 124-68-5 2-Amino-2-methyl-1-propanol 

Downstream Products

• 25452-20-4 2-<(2-chlorobenzyl)amino>-2-methyl-1-propanol 
• 112914-05-3 2-aminomethyl-4-(2-chlorobenzyl)-5,5-dimethylmorpholine 

Relevant articles and documents

Development of potent serotonin-3 (5-HT3) receptor antagonists. I. Structure-activity relationships of 2-alkoxy-4-amino-5-chlorobenzamide derivatives

A new series of 2-alkoxy-4-amino-5-chlorobenzamide derivatives hearing five- to seven-membered heteroalicyclic rings in the amine moiety was synthesized and evaluated for serotonin-3 (5-HT3) receptor antagonistic activity by assaying the ability to antagonize the yon Bezold-Jarisch reflex in rats. The five- to seven-membered heteroalicycles comprise pyrrolidine, morpholine, 1,4-thiazine, piperidine, piperazine, 1,4-oxazepine, 1,4- thiazepine, azepine, and 1,4-diazepine rings. Among them, some benzamide derivatives having a 1,4-diazepine ring showed a potent 5-HT3 receptor antagonistic activity. In particular, 4-amino-5-chloro-N-(1,4- dimethylhexahydro-1H-1,4-diazepin-6-yl)-2-ethoxyhenzamide (96) and the 1- benzyl-4-methylhexahydro-1H-1,4-diazepine analogue 103 showed potent 5-HT3 receptor antagonistic activity without 5-HT4 receptor binding affinity.