225640-36-8Relevant academic research and scientific papers
DNA cross-linking by a phototriggered dehydromonocrotaline progenitor
Tepe, Jetze J.,Williams, Robert M.
, p. 2951 - 2955 (1999)
A wide variety of pyrrolizidine alkaloids, such as monocrotaline, and the clinically significant mitomycins and the related FR-900482, FK 973, and FR-66979 exert their cytotoxicity through the formation of DNA-DNA interstrand cross-links and DNA-protein c
DNA cross-linking by a phototriggered pyrrolic progenitor developed from monocrotaline
Kosogof, Christi,Tepe, Jetze J,Williams, Robert M
, p. 6641 - 6643 (2007/10/03)
A wide variety of pyrrolizidine alkaloids, such as monocrotaline, exert their cytotoxicity through the formation of DNA-DNA interstrand cross-links and DNA-protein cross-links. These pyrrolizidine alkaloids are oxidatively activated in vivo forming a highly reactive pyrrolic-type intermediate, which is responsible for the DNA cross-linking reaction. The oxidative pathway of activation leads to undesired toxicity. Based on a previously reported photochemically triggered progenitor of monocrotaline, we describe here the semi-synthesis and DNA cross-linking of a dicarbamate analogue of the original phototriggered progenitor.
