225641-94-1 Usage
General Description
3,4-Difluorophenylglycine is a chemical compound with the molecular formula C8H7F2NO2. It is a derivative of glycine, an important neurotransmitter in the central nervous system. 3,4-Difluorophenylglycine is used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of specialty chemicals. 3,4-Difluorophenylglycine has potential applications in the field of medicinal chemistry, particularly in the development of drugs for neurological disorders. Its specific properties and reactivity make it a valuable building block for the creation of new compounds with potential therapeutic uses. Additionally, the incorporation of fluorine atoms into the chemical structure of 3,4-Difluorophenylglycine can enhance its bioavailability and metabolic stability, making it a promising candidate for drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 225641-94-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,5,6,4 and 1 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 225641-94:
(8*2)+(7*2)+(6*5)+(5*6)+(4*4)+(3*1)+(2*9)+(1*4)=131
131 % 10 = 1
So 225641-94-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H7F2NO2/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7H,11H2,(H,12,13)
225641-94-1Relevant articles and documents
Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists
Suzuki, Takao,Moriya, Minoru,Sakamoto, Toshihiro,Suga, Takuya,Kishino, Hiroyuki,Takahashi, Hidekazu,Ishikawa, Makoto,Nagai, Keita,Imai, Yumiko,Sekino, Etsuko,Ito, Masahiko,Iwaasa, Hisashi,Ishihara, Akane,Tokita, Shigeru,Kanatani, Akio,Sato, Nagaaki,Fukami, Takehiro
scheme or table, p. 3072 - 3077 (2010/02/28)
Optimization of high-throughput screening hit 1a led to the identification of a novel spiro-piperidine class of melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. Compound 3c was identified as a highly potent and selective MCH-1R antagonist, which has an IC50 value of 0.09 nM at hMCH-1R. The synthesis and structure-activity relationships of the novel spiro-piperidine MCH-1R antagonists are described.
