225645-27-2Relevant academic research and scientific papers
Synthesis, separation of E, Z isomers, their configuration by 1H NMR spectra and antifungal activity of new substituted 1,3-diphenyl-2-(1,2,4- triazol-1-yl)- prop-2-en-1-ones
Uchil, Vinod Rama,Joshi, Vidya
, p. 192 - 196 (2007/10/03)
ω- (1,2,4-Triazol-1-yl)4-chloroacetophenone 2 on condensation with substituted aryl aldehydes 3a-i in presence of piperidine (catalytic amount) and toluene gave new substituted triazolylpropenones (E) 4a-i and (Z) 5a-c isomers respectively. Their configuration has been determined by 1H NMR spectra. Compounds 4a, 4c, 4d, 4e and 5a have been found to have fungicidal activity against Trichophyton mentagrophytes, and Trichophyton rubrum. 4d is active even against Candida albicans.
