225656-32-6

Basic information

• Product Name: (R)-2-(Toluene-4-sulfonylamino)pent-4-enoic acid methyl ester
• Synonyms: (R)-2-(Toluene-4-sulfonylamino)pent-4-enoic acid methyl ester
• CAS NO: 225656-32-6
• Molecular Weight: 283.348
• Mol File: 225656-32-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-2-(Toluene-4-sulfonylamino)pent-4-enoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(Toluene-4-sulfonylamino)pent-4-enoic acid methyl ester(225656-32-6)
• EPA Substance Registry System: (R)-2-(Toluene-4-sulfonylamino)pent-4-enoic acid methyl ester(225656-32-6)

Safety Data

• Hazardous Substances Data: 225656-32-6(Hazardous Substances Data)

Upstream product

• 81136-73-4 (R)-2-allylglycine methyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 54594-06-8 D-allylglycine 
• 173723-62-1 methyl (2R)-2-amino-4-pentenoate hydrochloride 

Downstream Products

• 289716-58-1 (R)-2-{[(1R,4R)-4-Acetoxycyclopent-2-enyl](toluene-4-sulfonyl)amino}pent-4-enoic acid methyl ester 

Relevant articles and documents

A Stereoselective aza-Prins Reaction: Rapid Access to Enantiopure Piperidines and Pipecolic Acids

The aza-Prins reaction is a widely employed and highly efficient method for the preparation of saturated nitrogen-containing heterocycles. Its major drawback has always been a lack of diastereoselectivity and the formation of racemic products. Herein, we address these problems and report, for the first time, the synthesis of both diastereomerically and enantiopure multiply substituted piperidines via the aza-Prins reaction. This method is widely applicable for natural product synthesis and is exemplified here by the synthesis of enantiopure pipecolic acid derivatives.