225779-62-4

Upstream product

• 716336-82-2 (2S,5S)-5-(but-3-enyl)-2-(2-(trimethylsilyl)-ethynyl)-1-p-toluenesulfonylpyrrolidine 
• 916152-75-5 2-[(1S,6S)-9-(Toluene-4-sulfonyl)-9-aza-bicyclo[4.2.1]non-2-en-2-yl]-propane-1,2-diol 
• 716336-74-2 (1S,6S)-9-(Toluene-4-sulfonyl)-2-vinyl-9-aza-bicyclo[4.2.1]non-2-ene 
• 75-24-1 trimethylaluminum 
• 225779-59-9 9-tosyl-9-aza-1-methoxycarbonylbicyclo<4.2.1>non-1-ene 
• 98-59-9 p-toluenesulfonyl chloride 
• 716336-79-7 3-((2S,5R)-2-(tert-butyldiphenylsilyloxymethyl)-1-p-toluenesulfonylpyrrolidin-5-yl)-propan-1-ol 
• 716336-80-0 (2S,5S)-2-(tert-butyldiphenylsilyloxymethyl)-5-(but-3-enyl)-1-p-toluenesulfonylpyrrolidine 
• 716336-76-4 (S)-5-(3-(benzyloxy)propyl)-2-(tert-butyldiphenylsilyloxymethyl)-3,4-dihydro-2H-pyrrole 
• 716336-75-3 (2S,5S)-5-(but-3-enyl)-2-ethynyl-1-p-toluenesulfonylpyrrolidine 
• 916152-68-6 (2R,5S)-2-(3-Benzyloxy-propyl)-5-(tert-butyl-diphenyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-pyrrolidine 
• 916152-69-7 3-[(2R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionaldehyde 
• 916152-63-1 (2R,5S)-2-(3-Benzyloxy-propyl)-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidine 
• 916152-72-2 (2S,5S)-2-But-3-enyl-5-(2,2-dibromo-vinyl)-1-(toluene-4-sulfonyl)-pyrrolidine 

Relevant academic research and scientific papers

Concise Synthesis of (+)-[13C4]-Anatoxin-a by Dynamic Kinetic Resolution of a Cyclic Iminium Ion

An asymmetric total synthesis of [13C4]-anatoxin-a ([13C4]-1) has been developed from commercially available ethyl [13C4]-acetoacetate ([13C4]-15). The unique requirements associated with isotope incorporation inspired a new, robust, and highly scalable route, providing access to 0.110 g of this internal standard for use in the detection and precise quantification of anatoxin-a in freshwater. A highlight of the synthesis is a method that leverages a cyclic iminium ion racemization to achieve dynamic kinetic resolution in an enantioselective Morita–Baylis–Hillman (MBH) cyclization.

Further studies on enantioselective synthesis of (+)-anatoxin-a using enyne metathesis: unexpected inversion of chirality via a skeletal rearrangement of 9-azabicyclo[4.2.1]nonene derivative

The formal total synthesis of (+)-anatoxin-a was accomplished using enyne metathesis as a key step. It is very interesting that (+)-anatoxin-a was synthesized from (S)-pyroglutamic acid via an unusual inversion of chirality, which is rationalized in terms

Synthesis of (+)-anatoxin-a using enyne metathesis

Synthesis of N-tosylanatoxin-a was achieved by metathesis of enyne in cis-substituents on a pyrrolidine derivative. Metathesis reactions of enyne having terminal alkyne using various ruthenium-carbene complexes did not give a good results. However, when t

Asymmetric synthesis of (-)-anatoxin-a via an asymmetric cyclization using a new ligand for Pd-catalyzed alkylations

Palladium-catalyzed asymmetric allylic alkylations have been explored in the context of medium-sized ring substrates, intramolecular vs intermolecular processes involving attack on a formally meso π-allyl intermediate in the desymmetrization, and the pres