225785-54-6

Basic information

• Product Name: Nitrendipine Propyl Ester
• Synonyms: Nitrendipine Propyl Ester;Lercanidipine impurity 7;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl 5-Propyl Ester
• CAS NO: 225785-54-6
• Molecular Formula: C19H22N2O6
• Molecular Weight: 374.38778
• Mol File: 225785-54-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly, Sonicated), Methanol (Slightly)
• CAS DataBase Reference: Nitrendipine Propyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Nitrendipine Propyl Ester(225785-54-6)
• EPA Substance Registry System: Nitrendipine Propyl Ester(225785-54-6)

Safety Data

• Hazardous Substances Data: 225785-54-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 225785-54-6 differently. You can refer to the following data:
1. Nitrendipine Propyl Ester is an analogue of the antihypertensive drug Nitrendipine (N490150). Also, Nitrendipine Propyl Ester is an impurity of antihypertensive Lercanidipine (L179000). Lercanidipine impurity A.
2. Nitrendipine Propyl Ester is an analogue of the antihypertensive drug Nitrendipine (N490150). Also, Nitrendipine Propyl Ester is an impurity of antihypertensive Lercanidipine (L179000). Lercanidipine impurity A.

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 99-61-6 3-nitro-benzaldehyde 
• 53055-18-8 3-Aminocrotonsaeure-propylester 
• 39562-17-9 methyl 2-(3-nitrophenylmethylene)acetoacetate 

Relevant articles and documents

Synthesis and antihypertensive activity evaluation in spontaneously hypertensive rats of nitrendipine analogues

The antihypertensive activity of nitrendipine analogues can be improved by properly lengthening its alkyl chain in 3- or 5-position. Nitrendipine and its seven analogues were synthesized, and their antihypertensive activities in spontaneously hypertensive rats (SHR) were evaluated by ig administration. It was found that 5-n-heptyl 3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4- dihydropyridine- 3,5-dicarboxylate [(±)-5] exhibited the strongest antihypertensive effect amongst eight compounds. (?)-5-nheptyl 3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine- 3,5-dicarboxylate [(+)-5] was also prepared. Antihypertensive activities of (±)-5 and (?)-5 in SHR were compared. The results showed that (±)-5 and (?)-5 had a higher potency than nitrendipine, and (+)-isomer was 1.79-fold the raceme at a dose of 2 mg/kg. Springer Science+Business Media, LLC 2010.